Elucidation of the molecular pathways of lifespan extension by dietary restriction in yeast

In this dissertation, we demonstrate strong support for the antagonistic pleiotropy view of aging, reveal the illusion of sirtuin mediated longevity in 32 long lived alleles (hopefully steering the field farther from sirtuin research and toward more interesting things), show that there is indeed a conserved aging factor between CLS and RLS, indicate that aging in yeast is complex like any other organism and use phenotype clustering to show afg3∆ was within the Gcn4 pathway of lifespan extension, and finally bring nuclear tRNA and Gln3 into the light- showing that these could positively affect lifespan without reducing translation.

Author dc:creator

• Delaney, Joe Ryan

Advisor dc:contributor.advisor

• Kaeberlein, Matt K

• Aging; Cellular stress; Dietary restriction; Lifespan; Longevity; Yeast

Statement dc:rights

• Copyright is held by the individual authors.

Language dc:language.iso

en_US

Handle dc:identifier.uri

http://hdl.handle.net/1773/22019

OAI identifier oai:identifier

oai:digital.lib.washington.edu:1773/22019