Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 43 for “"Pleiotropy"”.
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Pleiotropy in complex traits
Genome-wide association studies (GWAS) have uncovered thousands of complex trait loci, many of which are associated with multiple phenotypes. The dedicated study of these pleiotropic effects is becoming increasingly common due to the availability of sample collections with high-dimensional …
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Pleiotropy and epistasis in auxin signaling networks
… extensive interconnections between pathways, pleiotropy, and overlapping gene expression. These complexities pose challenges in identifying candidate genes and parsing apart their isolated functions that could be strategically engineered to achieve desired plant phenotypes. Integration of …
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Towards precision medicine in psychiatry: investigating the contribution of cellular aging, pleiotropy and gender differences in psychiatric disorders and pharmacological response
… analytical approaches that allow to leverage pleiotropy to improve the yield of existing genome-wide summary statistics might also be of help to identify novel potential drug targets. In this thesis, we focus on the investigation of molecular markers related to cellular aging (telomere length) …
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Investigation of the Shared Genetic Influences on Bipolar Disorder, Borderline Personality Disorder and Regional Brain Structures
… area and thickness (N=37,479) were obtained. Pleiotropy and concordance were assessed using SNP-Effect Concordance Analysis. Conditional false discovery rate (cFDR) was used to condition BD and BPD GWAS results on genetic variants that influence brain regions. Linkage Disequilibrium Score …
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Deciphering Pleiotropic Effects: A Molecular Characterisation of the Foraging Gene in Drosophila melanogaster
Pleiotropy is defined as the manifold effects of a gene at the phenotypic level. Understanding the mechanisms of manifold gene action has important implications for many fields of biology ranging from evolution and to medicine. The foraging gene, in Drosophila melanogaster, has long been a pivotal …
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Elucidation of the molecular pathways of lifespan extension by dietary restriction in yeast
… demonstrate strong support for the antagonistic pleiotropy view of aging, reveal the illusion of sirtuin mediated longevity in 32 long lived alleles (hopefully steering the field farther from sirtuin research and toward more interesting things), show that there is indeed a conserved aging factor …
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Novel regulators of antibiotic biosynthesis in Serratia sp. ATCC 39006
… such as swimming motility and virulence. Pleiotropy was also found in the intergenic mutant: exhibiting enhanced antibiotic synthesis, and modified motility and virulence capacity. This intergenic insertion then led to the study of VfmE, an AraC-family transcription regulator, which …
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New insights in the molecular pathogenesis of neurofibromatosis type 1
… In addition, NF1 patients are prone to a pleiotropy of other phenotypic features. Determining when and in what cell type the crucial molecular defect actually occurs has proven to be surprisingly difficult for many NF1-related symptoms. Impeding factors include the large size of the NF1 …
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Quantitative genetic analysis of maize organogenesis
… have implications for our understanding of pleiotropy, translating to knowledge on their genomic architectures. This thesis's two core focuses are to i) develop novel understanding of the genetic architecture leaf angle and tassel primary branches and ii) reveal candidate pleiotropic genes …
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Predicting genetic interactions in Caenorhabditis elegans using machine learning
… with the likelihood of observing lethality or pleiotropy as well as observing genetic interactions. Our metric significantly outperforms other established network metrics such as degree or betweenness. Next, we show how Bayesian sets can be applied to gain intuition as to which datasets are the …
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An Exploration of Fitness Landscapes: Theory and Experiments
… problem. I find that restricting the level of pleiotropy and restricting the number of maladapted traits simultaneously solves the paradox, and maintains fits to other experimental data. To complement this modeling, I spend the second two results chapters discussing experimental results. I …
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Disease escape in relation to a trade off between septoria tritici blotch and yield of wheat
… and yield effects are connected by linkage or pleiotropy.
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Identification and genetic characterization of tobacco accessions possessing resistance to tobacco cyst nematode
… to TCN. This result seems to rule out pleiotropy and is consistent with the assertion that the two resistance genes are closely linked. six TCN resistant lines and two susceptible lines were selected and a diallel study was conducted to determine the inheritance of resistance to TCN. …
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Signatures of natural selection and local adaptation in Populus trichocarpa and Populus deltoides along latitudinal clines
… functional groups of genes irrespective of pleiotropy. Further, upstream regions of all genes showed high selective constraint, with some of them (FT-2, PIF-4, FRIGIDA) showing significantly higher variation than the other genes, hinting at the role of non-coding regulatory regions in local …
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Pheromones, nectar, and computer vision: investigating large-scale patterns of chemodiversity.
… plant - pollinator interactions. The Nectar Pleiotropy hypothesis suggests that the presence of specialized metabolites in nectar is non-adaptive, and that these compounds are maintained in the nectar solely through selective pressures for antiherbivore chemistry in leaves and floral tissues. …
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The Phenotypic Impact of Transgenic Flower Color Variation in Ipomoea quamoclit.
… and examine fitness associated with traits. Pleiotropy is a potentially confounding effect of this approach and must be addressed before genetic engineering may be used as an experimental approach to address experimental questions. This research looked at the pleiotropic effects of a single …
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Avoiding trade-off when enhancing Fusarium head blight resistance of barley
… in this region is not due to linkage or pleiotropy with these traits. In contrast, FHB resistance within the A×T population was coincident with both height and heading date QTL on 3H. QTL analysis of malting traits of Chevallier, an English malting landrace, was also undertaken. …
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Genetic basis of adaptive radiation in East African cichlids
… in hybrid progeny, suggesting a degree of pleiotropy among genes that underlie differences in the cichlid feeding apparatus. Finally, I constructed a genetic linkage map for Lake Malawi's rock-dwelling cichlids, and identified quantitative trait loci (QTL) that affected shape differences in …
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Loblolly Pine Genetics Structure Its Mycorrhizal Community
… genetic correlations between traits (driven by pleiotropy or linkage disequilibrium) could influence how species evolve under multiple, conflicting selection pressures, potentially either constraining or enhancing the adaptation of species to each other. The interaction between mycorrhizal fungi …
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The biology of ageing: pro- and anti-ageing signals from the reproductive system
… survival, which ends in death. The antagonistic pleiotropy theory for ageing suggests selection favours genes with positive effects on early life even if detrimental effects are observed in later life, indicating a trade-off between lifespan and reproductive output. Ageing, however, is a complex …
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