Fluorinated amino acid derivatives

A new approach in the syntheses of 3-bromo-2-butanone and 2-bromo-3-fluorobutane has been developed. All attempts to alkylate the sodium salt of diethyl malonate, ethyl acetoacetate, or diethyl acetamidomalonate with 2-bromo-3-fluorobutane failed. New phosphonoacetates, tert-butyl and benzyl diethylphosphono-acetates were prepared as very versatile intermediates in the syntheses of carboxylic acids. Methyl-, ethyl-, tert-butyl-, and benzyl 4-fluoro-3-methyl-2-pentenoates were synthesized in high yields by the Horner-Emmons reaction. The reaction is stereoselective and gave E and Z form in 75:25 ratio as determined from proton and fluorine nmr spectra. A long-range coupling was observed in fluorine nmr spectrum of 3-fluoro-2-butanone. From the ethyl 4-fluoro-3-methyl-2-pentenoate, ethyl 2-bromo-4-fluoro-3-methyl-2-pentenoate was prepared, but the latter could not be reduced under the conditions of catalytic hydrogenation. Ethyl 2-chloro-4-fluoro-3-methyl-2-pentenoate was prepared from 3-fluoro-2-butanone and ethyl diethylphosphonochloroacetate, but could not be reduced. Catalytic hydrogenation of alky 4-fluoro-3-methyl-2-pentenoates gave the corresponding saturated esters in high yields. Treatment of alkyl 4-fluoro-3-methylpentanoates with lithium diisopropylamide and bromine at -78° yielded the corresponding 2-bromoderivatives. Methyl-, ethyl-, and tert-butyl 2-bromo-4-fluoro-3-methyl-pentanoates were treated with sodium azide to give the corresponding 2-azido derivatives which were further reduced into methyl-, ethyl-, and tert-butyl 2-amino-4-fluoro-3-methylpentanoates.

Name thesis:degree_name

Ph. D.

Level thesis:degree_level

doctoral

Discipline thesis:degree_discipline

Chemistry

Department dc:contributor.department

Chemistry

Grantor dc:publisher

Virginia Polytechnic Institute and State University

Year dc:date.issued

1975

Author dc:creator

• Butina, Darko

Statement dc:rights

• In Copyright

Licence dc:rights.uri

• http://rightsstatements.org/vocab/InC/1.0/

Language dc:language.iso

en_US

Handle dc:identifier.uri

http://hdl.handle.net/10919/76531

OAI identifier oai:identifier

oai:vtechworks.lib.vt.edu:10919/76531