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Showing 1 to 20 of 27 for “"acetoacetate"”.
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The effect of acetoacetate, organosulfur compounds and hormones on the activity of the liver mitochondria
… pig and bovine ketosis. Addition of sodium acetoacetate to the reaction medium resulted in depressed oxidation of pyruvate and 1-ketoglutarate of isolated normal rat liver mitochondria.
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THE RELATIONSHIP BETWEEN BRAIN AND SYSTEMIC METABOLISM IN ALZHEIMER’S DISEASE AS ASSESSED BY DUAL-TRACER ACETOACETATE/FLUORODEOXYGLUCOSE PET IMAGING
Alzheimer’s disease (AD) is a fatal neurodegenerative disorder that afflicts an estimated 5.4 million people in the United States. Cerebral metabolic dysfunction is a well-established feature of AD. Despite an established relationship between systemic metabolic disease and AD we know very little …
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The Cloning of a Putative Regulatory Gene and the sol Region from Clostridium beijerinckii
… ald (aldehyde dehydrogenase), ctfA and ctfB (acetoacetate: butyrate/acetate CoA-transferase) and part of adc (acetoacetate decarboxylase) was cloned and sequenced. The organization of these genes was similar to that in C. beijerinckii NRRL B593. Northern analysis indicated that these four …
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Structure/property behavior of inorganic/organic sol-gel derived hybrid materials
… or titanium tetra-iso-propoxide with ethyl acetoacetate reacted with the triethoxysilane end capped PTMO. The hybrid networks were optically clear and could be easily formed as relatively large monoliths. A novel method of preparation of stable sols without the use of ethyl acetoacetate, …
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A Quantitative Analysis of Solvent Effects on Keto-Enol Tautomeric Equilibria
… anthrone, acetylacetone, ethyl acetoacetate and 3-oxabicyclo{4.3.0}-2,9-dioxononane, representative of the major classes of (beta)-dicarbonyl and phenolic tautomeric equilibria, are determined in a variety of solvents by high dilution FT NMR and UV studies. O-Methylated enol …
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Blister Test for Measurements of Adhesion and Adhesion Degradation of Organic Polymers on AA2024-T3
… coating (CC) on the adhesion strength of acetoacetate to AA2024-T3 and the effects of improper water rinse temperature after cleaner were assessed using the BT. The results showed that pretreatments improve the adhesion strength of acetoacetate primer on AA2024-T3, but the comparative …
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Genetic and Physiological Characterization of Clostridium Beijerinckii BA101 and NCIMB 8052
… the specific activities of CoA transferase, acetoacetate decarboxylase and butyraldehyde dehydrogenase were higher in BA101 than in NCIMB 8052. mRNA expression levels of the sol operon were also elevated during the exponential and early stationary growth phases in BA101. The increased …
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Nickel-catalyzed reductive coupling reactions of 1,6-enynes and the total synthesis of (+)-acutiphycin
… the longest linear sequence from either methyl acetoacetate or isobutyraldehyde. ...
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Topology and Telechelic Functionality Control in Polyester Design
… time using base-catalyzed Michael addition of acetoacetate functionalized polyesters with acrylates. Linear and star-shaped poly(caprolactone) (PCL) oligomers with different molecular weights were functionalized and crosslinked. Thermomechanical properties were evaluated as a function of …
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Quantitative analysis of carbon fluxes for fat biosynthesis in wild-type and IRS-1 knockout brown adipocytes
… relative contribution of glucose, glutamine, and acetoacetate to fat biosynthesis in wild-type (WT) and insulin receptor substrate-i knockout (IRS-1 KO) brown adipocytes were analyzed by stable-isotope labeling, GC/MS, and flux estimation. Glutamine contributed more to fatty acid synthesis than …
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Studies of tartaric acid modified nickel supported catalysts for enantioselective hydrogenation reactions
… in the enantioselective hydrogenation of methyl acetoacetate to methyl 3‐hydroxybutyrate. Variables of reaction during modification such as pH and tartaric acid concentration, as well as Ni particle size above a minimum threshold of ca. 20 nm, proved not to have a major effect on …
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Fluorinated amino acid derivatives
… the sodium salt of diethyl malonate, ethyl acetoacetate, or diethyl acetamidomalonate with 2-bromo-3-fluorobutane failed. New phosphonoacetates, tert-butyl and benzyl diethylphosphono-acetates were prepared as very versatile intermediates in the syntheses of carboxylic acids. Methyl-, …
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Nitrogen Metabolism and Solvent Production in Clostridium Beijerinckii Nrrl B593
… activity. Measurement of specific activities of acetoacetate decarboxylase and aldehyde dehydrogenase and Northern blot analysis of the mRNA of the solvent-producing genes in samples harvested periodically from a nitrogen-fixing culture of C. beijerinckii showed the presence of both enzyme …
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Studies of liquid phase intermolecular interactions utilizing ¹H and ¹³C dynamic nuclear polarization and nuclear magnetic resonance techniques
… acetone, acetaldehyde, diethyl malonate, ethyl acetoacetate, diphenylmethane, and triphenylmethane. These molecules represent a wide range of functional groups with different acidities of the respective carbon-hydrogen bonds. The ¹³C DNP results demonstrated that the scalar dominated enhancement …
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Energy levels and anaerobic endproducts in the brains of two species of teleost fish at death in anoxic water
… ketone bodies (betaâ hydroxybutyrate and acetoacetate), or alternative anaerobic endproducts (succinate, alanine, propionate, isobutyrate, isovalerate, and ethanol). Lactic acid increased two-fold with anoxia. The bullhead was able to generate ATP by depleting its CrP stores and through …
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Hepatic acetogenesis and ketogenesis in neonatal swine
… bodies ($\beta$-hydroxybutyrate, $\beta$-OHB & acetoacetate) in suckling piglets and evidence of minimal hepatic ketone body production from fatty acids in vitro suggested that, unlike previously-studied neonates, enhanced ketogenesis does not characterize the metabolism of the newborn pig. This …
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Stereoselective synthesis of perhydrobenzo[4.5.6]cholestanes
… series of reactions was performed on the 3α-acetoacetate, leading finally to formation of 3α-hydroxy-4β,5α-dihydrobenzo[4.5.6]cholestan-5'(6'H)-one. Modification of foregoing reaction conditions, resulted in the design of a tandem Michael-aldol sequence, in which the 3-acetoacetates could be …
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Metabolism in vivo of 1, 3-butanediol in the rat
… rise to increased D-(-)- S -hydroxybutyrate and acetoacetate in systems which contained liver slices or liver slices plus diaphragm. In addition, the production rate of D-(-)- S - hydroxybutyric acid was higher than that of acetoacetate in the pre sence of BD, while the opposite was true in its …
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3-Hydroxy-3-methylglutaryl-coenzyme A lyase: investigation of cysteines mediating intersubunit disulfide formation and regulation by thiol/disulfide exchange and discovery of an extramitochondrial homolog
… of 3-hydroxy- 3-methylglutaryl-Coenzyme A into acetoacetate and acetyl-Coenzyme A, a key reaction in ketogenesis and leucine catabolism. Previous work prompted the hypothesis that in the absence of reductant, cysteine 323 forms a disulfide bond with cysteine 323 on the adjacent monomer, blocking …
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The Effect of The Modification of The Acidic and Zwitterionic Phospholipid Composition on The Enzymatic Activity of D-Beta-Hydroxybutyrate Dehydrogenase
… choline supplemented cells while the K(,m) for acetoacetate remained unaffected. The data suggest that the enzymatic activity of BDH is sensitive to the phosphatidylcholine content in the submitochondrial membrane. Thus, the results of this study show that the apparent K(,m) of BDH can be …
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