The action of selenite on ATP synthesis in rat lens

A subcutaneous injection of sodium selenite (30 umol/kg body weight) in 10â day old rats produced a cataract within 72 hours. Lens opacification was preceded by a 15% decrease in ATP content. Lens ATP did not fully recover to control concentrations by 11 days post-injection. A moderate correlation existed between lens weight and total ATP content in control lenses <r=O.509, n=153), but this relationship disappeared with selenite treatment <r=0.023, n=153). There was a significant inhibition by selenite on lens growth from 4 through 11 days after an injection.

Name thesis:degree_name

Master of Science

Level thesis:degree_level

masters

Discipline thesis:degree_discipline

Biochemistry and Nutrition

Department dc:contributor.department

Biochemistry and Nutrition

Grantor dc:publisher

Virginia Tech

Year dc:date.issued

1986

Author dc:creator

• Adamchak, Marsha Ann

Chair dc:contributor.committeechair

• Hess, John L.

Committee members dc:contributor.committeemember

• Bunce, George Edwin
• Gregory, Eugene M.

Statement dc:rights

• In Copyright

Licence dc:rights.uri

• http://rightsstatements.org/vocab/InC/1.0/

Language dc:language.iso

en

Dc Identifier Other

etd-11142012-040119

OAI identifier oai:identifier

oai:vtechworks.lib.vt.edu:10919/45655