Virginia Tech
The role of the apparent rate constant of cross-bridge transition from the strong binding state (G app ) in skeletal muscle force production
Abstract
dc:description.abstractForce regulation at the level of the actin-myosin cross-bridge (XB) can be described by a 2 state model in which the XB's cycle between a strongly bound (SB), force generating state and a weakly bound (WB), non-force generating state. This cycle can be characterized by the apparent rate constants for transition into the SB state (fapp) and returning to the WB state (gapp), Increases in XB force can be accounted for by an increase in fapp a decrease in gapp., or both. While effort towards understanding XB force regulation has focused on the notion that force production is primarily regulated by fapp the purpose of this investigation was to determine if gapp continues to force regulation at the XB and to determine whether gapp differs in,muscles with differing contractile characteristics.
Degree
thesis:*- Name thesis:degree_name
- Ph. D.
- Level thesis:degree_level
- doctoral
- Discipline thesis:degree_discipline
- Veterinary Medical Sciences
- Department dc:contributor.department
- Veterinary Medical Sciences
- Grantor dc:publisher
- Virginia Tech
- Year dc:date.issued
- 1996
Author and committee
dc:creator, dc:contributor.*- Author dc:creator
-
- Ward, Christopher W.
- Chairs dc:contributor.committeechair
-
- Lee, John C.
- Williams, Jay H.
- Committee members dc:contributor.committeemember
-
- Eng, Ludeman A.
- Klug, Gary A.
- McGrath, Charles J.
Subjects
dc:subject × 5Rights
dc:rights- Statement dc:rights
-
- In Copyright
- Licence dc:rights.uri
- Language dc:language.iso
- en
Identifiers
dc:identifier.*- Dc Identifier Other
- etd-06062008-151126
- OAI identifier oai:identifier
- oai:vtechworks.lib.vt.edu:10919/37983