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Virginia Tech

Modeling of Ethanol Metabolism and Transdermal Transport

Abstract

dc:description.abstract

Approximately 14,500 people were killed in traffic crashes where the driver was legally intoxicated in 2005, constituting 33% of all traffic fatalities that year. While social efforts to reduce the number of traffic fatalities have shown to be moderately successful, alcohol has remained a factor in 40% of all traffic deaths over the past decade. Transdermal ethanol detection is a promising method that could prevent drunk driving if integrated into an ignition interlock system; potentially preventing 90 million drunk driving trips a year in the US. However, experimental data from previous research has shown significant time delays between alcohol ingestion and detection at the skin which makes real time estimation of blood alcohol concentration via skin measurement difficult. Using a validated model we studied the effects that body weight, metabolic rate and ethanol dose had on the time lag between the blood alcohol concentration and transdermal alcohol concentration. The dose of alcohol ingested was found to have the most significant effect on the skin alcohol lag time. Additionally, custom transdermal ethanol sensors were designed and fabricated and a pilot study on human subjects was conducted to determine if inexpensive transdermal ethanol sensors could be used to detect alcohol in drivers.

Degree

thesis:*
Name thesis:degree_name
Master of Science
Level thesis:degree_level
masters
Discipline thesis:degree_discipline
Mechanical Engineering
Department dc:contributor.department
Mechanical Engineering
Grantor dc:publisher
Virginia Tech
Year dc:date.issued
2008

Author and committee

dc:creator, dc:contributor.*
Author dc:creator
  • Webster, Gregory Daniel
Chairs dc:contributor.committeechair
  • Gabler, Hampton Clay
  • Duma, Stefan M.
Committee member dc:contributor.committeemember
  • Grant, John Wallace

Subjects

dc:subject × 6

Rights

dc:rights
Statement dc:rights
  • In Copyright

Identifiers

dc:identifier.*
Dc Identifier Other
etd-06062008-115843
OAI identifier oai:identifier
oai:vtechworks.lib.vt.edu:10919/33456

Chain of custody

source
Harvested from
Virginia Tech
Base URL
vtechworks.lib.vt.edu/oai/request
Last updated
2026-07-22
Source record
OAI-PMH GetRecord
citation

Webster, Gregory Daniel. Modeling of Ethanol Metabolism and Transdermal Transport. masters thesis, Virginia Tech, 2008. http://hdl.handle.net/10919/33456