Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 101 for “"Transdermal"”.
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Transdermal Iontophoretic Delivery Of Lipophilic Drugs
… widely studied active technique for enhancing transdermal delivery of drugs. However, its ability to enhance the delivery of highly lipophilic compounds is poor due to lack of any charge and poor water solubility of molecules. Propofol, a sedative and anesthetic drug was chosen as a one of the …
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Fiberoptic Microneedles for Transdermal Light Delivery
Shallow light penetration in tissue has been a technical barrier to the development of photothermal therapies for cancers in the epithelial tissues and skin. This problem can potentially be solved by utilizing minimally invasive probes to deliver light directly to target areas potentially > 2 mm …
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Elucidation of chemically-induced transdermal transport processes
In this thesis, chemically-induced transdermal transport enhancement has been examined as one of the many techniques currently used to increase the skin permeability to a broader range of pharmaceutically relevant drugs. By taking advantage of the current developments in instrumentation technology, …
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Transdermal photopolymerization of hydrogels for tissue engineering
Thesis (Ph.D.)--Harvard--Massachusetts Institute of Technology Division of Health Sciences and Technology, 1999.
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Modeling of Ethanol Metabolism and Transdermal Transport
… 40% of all traffic deaths over the past decade. Transdermal ethanol detection is a promising method that could prevent drunk driving if integrated into an ignition interlock system; potentially preventing 90 million drunk driving trips a year in the US. However, experimental data from previous …
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An investigation of some factors affecting transdermal permeation.
Factors affecting transdermal permeation were investigated using Differential Thermal Anlaysis (DTA) and in vitro penetration studies of neonatal rat stratum corneum (s.c.), with radiolabelled propanol and hexanol as penetrants. Thermogravimetric Analysis, Thin-Layer Chromatography (TLC) and …
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Microneedle-mediated transdermal drug delivery of biotherapeutic macromolecules
… the many drawbacks associated with this method. Transdermal delivery has been an attractive alternative for many pharmaceutical formulators. However, few drugs possess the appropriate physicochemical properties required for crossing the human skin barrier. Microneedle (MN) technology combines …
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Polymeric microneedle systems for enhanced transdermal drug delivery
… by advanced drug delivery methods like enhanced transdermal drug delivery. Delivery across skin offers many advantages compared to oral or parenteral routes e.g. non-invasive, avoiding first-past metabolism, improved bioavailability and reduction of systemic side effects. Microneedle (MN) are …
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Mechanisms of chemical and physical transdermal penetration enhancement
The underlying theme of this thesis is one of exploring the processes involved in the enhancement of percutaneous absorption. The development of an attenuated total reflectance Fourier-Transform infrared (ATR-FTIR) spectroscopic method to analyse diffusion of suitable topically applied compounds in …
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Ultrasound-mediated transdermal drug delivery : mechanisms and applications
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemical Engineering, 1996.
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A controllable, nano-volumetric, transdermal drug delivery device
Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 2002.
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Linker-based Lecithin Microemulsions as Transdermal Drug Delivery Systems
The interest in microemulsions as transdermal delivery systems have been motivated by their large surface area for mass transfer, their high solubilization capacity of hydrophobic actives, and their ability to improve skin penetration. Lecithins (mixtures of phospholipids similar to those find in …
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Diffusivity of drug actives in transdermal drug delivery (TDD)
Transdermal Drug Delivery (TDD) through skin patches has many advantages including the following: slow and continuous administration of the therapeutic over long periods of time, timely dosage, accessibility, kinetic maneuverability, elimination of the "First Pass Effect" and negative side effects …
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Design and evaluation of hot melt extruded transdermal patches.
… has been a growing interest towards the use of transdermal drug delivery systems (TDDS). However, a great challenge in this arena is the formidable barrier posed by the skin that can limit permeation of therapeutic agents. Therefore, there is a need for novel strategies or enhancement techniques …
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Biophysical aspects of transdermal drug delivery and chemical enhancement
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemical Engineering, 1996.
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Does Transdermal Nicotine-Induced Withdrawal Suppression Depend on Smokers' Gender?
… this indication, and several forms, including transdermal nicotine (TN) are available over-the-counter in the United States. NRT is less efficacious in women than in men, although the specific reasons for this gender difference are unknown. NRT generally, and TN specifically, is thought to …
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An investigation of the effect of surfactants on transdermal permeation.
The aim of this study was to investigate the direct effects of surfactants on the stratum corneum, and thus propose mechanisms of action for these compounds as penetration enhancers. The main methods used in the study were: determination of the permeability of neonatal rat stratum corneum to …
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Development and formulation of wax-based transdermal drug delivery systems
Topical and transdermal formulations are promising platforms for the delivery of drugs. A unit dose topical or transdermal drug delivery system that optimises the solubility of drugs within the vehicle provides a novel dosage form for efficacious delivery that also offers a simple manufacture …
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Role of cavitation, surfactants, and their synergism in transdermal sonophoresis
… of low-frequency ultrasound-mediated transdermal drug delivery. Specifically, while prior research has focused on a more general understanding of the mechanisms associated with low-frequency sonophoresis (LFS), this thesis directly investigates the mechanisms associated with phenomena …
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A conformable ultrasound patch for cavitation enhanced transdermal cosmeceutical delivery
… demands a safe and effective method to increase transdermal absorption of innovative therapeutic cosmeceuticals. However, permeation of small-molecule drugs is limited by the innate barrier function of the stratum corneum. Here, we report a conformable ultrasound patch (cUSP) that enhances …
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