Retention trends of chemical classes using CCl₄ as a carrier solvent in normal-phase HPLC

Carbon tetrachloride (CCl₄ ) was closely evaluated as a carrier solvent in high-performance liquid chromatography (HPLC). The separation and retention trends of ninety-two selected compounds from eleven chemical classes (furans, thiophenes, aromatic hydrocarbons, ethers, esters, ketones, aldehydes, aromatic amines, azaarenes, alcohols and phenols) on three analytical silica-bonded phase (amino (NH₂), cyano (CN) and polar amino-cyano (PAC)) columns were investigated with CCl₄ and refractive index (RI) detection. The sample capacity and column efficiency of each of the NH₂ and PAC columns were measured and compared. Besides, a method of determining unmeasurable capacity factors (k' values) was found and illustrated.

Name thesis:degree_name

M.S.

Level thesis:degree_level

masters

Discipline thesis:degree_discipline

Chemistry

Department dc:contributor.department

Chemistry

Grantor dc:publisher

Virginia Polytechnic Institute and State University

Year dc:date.issued

1985

Author dc:creator

• Wang, Muh S.

Statement dc:rights

• In Copyright

Licence dc:rights.uri

• http://rightsstatements.org/vocab/InC/1.0/

Language dc:language.iso

en

Handle dc:identifier.uri

http://hdl.handle.net/10919/106063

OAI identifier oai:identifier

oai:vtechworks.lib.vt.edu:10919/106063