Sub threshold high frequency electrical field stimulation effect for angiogenesis and vegf expression in cardiomyocytes and heart tissue. Remodelling in the heart: impact of mechanical stretch, threshold and sub-threshold electrical stimulation on cultivated cardiomyocytes and sympathetic neurons /

To evaluate growth factors response to various stimulation techniques in the field of neurocardiology. This research asses the influence of electric field and stretching effect on biologically active proteins. In this work the following research tasks are answered: To investigate the effect of sub threshold electrical stimulation on vascular endothelial growth factor regulation in cultured neonatal rat ventricular myocytes. To evaluate the role of autoantibodies in cases of dilated cardiomyopathy, inducing the expression of vascular endothelial growth factor in cardiomyocytes; to evaluate the effect of contraction and the secretion of vascular endothelial growth factor as a cell response to stretching. Investigate the effect of high frequencies, irregular stimulation on vascular myocytes and their nerve growth factor. To evaluate the response of the sympathetic system neurons to mechanical stretching in the evaluation of biologically active substances such as vascular endothelial growth and neuronal growth factors. Up to now, studies have shown that high-frequency threshold or sub-threshold electrical stimulation can lead to the production of biologically active molecules in non-cardiac tissues. Meanwhile, based on this study, we show that viable myocytes can produce bioactive proteins that have a positive effect on cell proliferation and vitality of endothelium cells in vitro.

Grantor dc:publisher

Institutional Repository of Vilnius University

Year dc:date

2018

Author dc:creator

• Račkauskas, Gediminas,

Contributors dc:contributor

• Aidietis, Audrius

• up to threshold stimulation ; high frequency stimulation ; cardiomyocytes ; neurocytes ; angiogenesis

Statement dc:rights

• info:eu-repo/semantics/openAccess

Language dc:language

eng

Repository record dc:identifier

https://repository.vu.lt/VU:ELABAETD31265995&prefLang=en_US

OAI identifier oai:identifier

oai:vu.lt:elaba:31265995