Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 16 of 16 for “"Cardiac tissues"”.
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Characterisation of cardiac protein changes post death: pilot study
… a need to evaluate the structural integrity of tissues during the PM to see whether they might serve as a control for research. This implies that before using these tissues as controls, biomolecule stability in these tissues needed to be assessed. Therefore, it is equally crucial to investigate …
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Controlling Arrhythmias Using Optogenetic Actuators in Computational Simulations
… models of heart cells (cardiomyocytes), cardiac tissues, and heart chambers to control arrhythmia development. Chapter 1 presents an overview of cardiac anatomy, relevant physiology, and cardiac electrophysiology computational models. Chapter 2 provides a basic explanation of optogenetic …
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Sub threshold high frequency electrical field stimulation effect for angiogenesis and vegf expression in cardiomyocytes and heart tissue. Remodelling in the heart: impact of mechanical stretch, threshold and sub-threshold electrical stimulation on cultivated cardiomyocytes and sympathetic neurons /
… of biologically active molecules in non-cardiac tissues. Meanwhile, based on this study, we show that viable myocytes can produce bioactive proteins that have a positive effect on cell proliferation and vitality of endothelium cells in vitro.
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Heart in Polycystic Kidney Disease is Characterized by Cardiac Dysfunction and Structural Deformation
… Sex- and age-matched human heart tissues from non-PKD and PKD were studied and verified in a heart-specific PKD mouse model. Structural and functional abnormalities of cardiac tissues and fibrosis-associated pathways were analyzed.</p> <p><strong>Results:</strong> Human PKD …
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Expression of atrial natriuretic factor in transgenic potatoes
… transcripts comigrating with that from murine cardiac tissues. The activity of the 35S and patatin promoters was found to be appropriate with respect to tissue/organ specificity. Under the 35S promoter, ANF and GUS mRNA accumulated to much higher levels in leaves compared with tubers. Patatin …
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Dendrimer Nanoconjugates And Their Oral Inhalation Formulations For Lung Cancer Therapy
… Another major challenge in the use of DOX is its cardiac toxicity. Free DOX in bloodstream can accumulate in cardiac tissues, thus leading to fatal heart damages. On the other hand, the lungs are considered as a portal to external environment and suitable for local delivery. Additionally, oral …
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From iPSCs to Engineered Heart and Liver Models: Modulating Genetic and Extracellular State for Maturity
… fidelity and utility of iPSC-derived hepatic and cardiac models. For hepatic differentiation, we employed RNA-seq and ATAC-seq across key differentiation stages to identify transcription factors and signaling pathways regulating hepatic fate. Three independent computational pipelines converged on …
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Microtechnologies for Cardiovascular Tissue Engineering
… this disease burden though the fabrication of cardiac and vascular tissues in vitro. However, the challenges for achieving these aims are significant - for cardiac tissues, the therapy must adhere to strict requirements of adequate perfusion and functional integration with the damaged heart. …
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Ultra-Wideband Imaging System For Medical Applications. Simulation models and Experimental Investigations for Early Breast Cancer & Bone Fracture Detection Using UWB Microwave Sensors
… as early breast cancer detection, analysis of cardiac tissues, soft tissues and bones. Microwave imaging uses non-ionizing ultra wideband (UWB) electromagnetic signals and utilises tissue-dependent dielectric contrast to reconstruct signals and images using radar-based or tomographic imaging …
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Modelling of Residual Stresses of Blood Vessels
… of arterial walls. It was developed for cardiac tissues by Skatulla et al. (2014), but it can also be used for a preliminary investigation on arterial tissues as these two types of tissues exhibit comparable mechanics. Residual stresses are incorporated by using three problem definitions, …
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MUTAGENESIS OF AAV CAPSID PROTEINS FOR ENHANCED TRANSDUCTION OF CARDIAC CELL TYPES
… 9 (AAV9) has a high transduction efficiency for cardiac tissues, along with liver, skeletal muscle, pancreatic tissue, and the eye, versus other AAV serotypes. Unfortunately, nonspecific targeting to the intended tissue can result in the need for use of higher particle numbers to obtain intended …
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Modulation of mitogenic signaling and growth by sympathetic adrenergic regulation
… United States. Both diseases are associated with cardiac remodeling, including cellular growth and fibrosis. Central to the progression of heart disease and diabetes are the adrenergic receptors (ARs) and insulin receptors (IR), respectively. Classically considered to elicit separate, and even …
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4D Control of Tissue Development and Blood Vasculature using Photo-mediated Chemistries
… set of tools required to create de novo tissues or organs. This thesis aims to address these pertinent hurdles in tissue engineering by exploring new means to generate complex tissues using a combination of tunable synthetic hydrogels and photo-mediated chemistries. A preliminary data …
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Intracellular calcium mobilization in cardiomyocytes of rats with experimental diabetes
… in the heart are among the major causes of cardiac dysfunction. To study the mechanism(s) involved in the development of diabetic cardio myopathy, [Ca2]i (determined by fluorescence microscopy and Ca-indicators) and contraction of the cardiomyocytes (measured by a video-edge detector system) …
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Correlating with Local Variation in Collagen Level and Mechanical Properties of the Heart Tissues
… to determine the mechanical properties of the cardiac tissue. The introduced method combined a finite element modeling with the experimentally obtained images from the left and right ventricles to develop a model for calculating the shear modulus, Young's modulus, and the Poisson's ratio of the …
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Growth and chemical functionalization of SiC nanowires for biomedical applications in cardiology and oncology
… these diseases is still long, and cancer and cardiac diseases remain a serious socio-economic problem for our society. For this reason, this PhD research focuses on these two main topics; called in the thesis the oncology project and the cardiology project. Both projects were devoted to the …