Bioaktyviųjų joninių skysčių aukštosios skyros BMR tyrimas /

Bioactive room temperature ionic liquids (b-RTIL) are getting more popular in the field of ionic liquids. The ionic liquids are composed of organic cation molecules and organic or inorganic molecule anions. IL have low melting temperature; low vapour pressure and their chemical structure can be altered. b-RTILs are different from the regular IL since b-RTILs are compatible with the human organism. That means, that b-RTIL can be used in medicine by increasing drug solubility in water. NMR spectroscopy is used to analyse b-RTILs – choline lysinate, choline tryptophanate and choline glycinate ([Ch][Lys], [Ch][Trp] and [Ch][Gly]). Also, with NMR we can analyse [Ch][Lys] interaction with water molecules by measuring the chemical shift of both water molecule and [Ch][Lys] protons at the b-RTIL concentration between 10-5 and 1 molar fraction. [Ch][Lys] cation protons’ chemical shifts reach the plateau at χ_RTIL=10^(-4). molar fraction. The chemical shifts of [Lys] anion protons do not reach the plateau at the measured concentration interval. Water molecule chemical shift plateaus at χ_RTIL=1,5×10^(-2) molar fraction. In [Ch][Trp] water mixture, all molecules chemical shift plateaus at χ_RTIL=10^(-4) molar fraction. In [Ch][Gly] cation protons chemical shift stabilizes at a concentration of χ_RTIL=〖4×10〗^(-4) molar fraction while anion proton chemical shift stabilizes at 〖2,5×10〗^(-5) molar fraction. Water chemical shift plateaus at a concentration of 2×10^(-5) molar fraction.

Grantor dc:publisher

Institutional Repository of Vilnius University

Year dc:date

2024

Author dc:creator

• Mikalauskas, Lukas,

Statement dc:rights

• info:eu-repo/semantics/openAccess

Language dc:language

lit

Repository record dc:identifier

https://repository.vu.lt/VU:ELABAETD210578007&prefLang=en_US

OAI identifier oai:identifier

oai:vu.lt:elaba:210578007