Synthesis and investigation of functionalized alkyl oligo(ethylene oxides) /

Oligo(ethylene oxide) thiols and sulphides are the main building blocks for self-assembled monolayers. Derivatives, functionalized with glicerolipid, biotin and cholesterol groups are the most popular tools used in attachments, further development and investigation of artificial membranes. In this work monoprotection of glycerol by p-methoxybenzylalcohol was optimized, allowing separation of products by simple extraction methods. New glycerol compounds, with different blocking groups, were synthesized. These perspective derivatives are convenient for the synthesis of unsymmetrical lipids. An effective synthesis route of several steps and isolation method without column chromatography for the synthesis of thiolipids were also discovered. New functionalized biotins were synthesized for tethering of biological objects. Vibrational bands of new 4,4ʹ-disubstitute-1,2-ditholanes were assigned by the theoretical calculation and analysis of potential energy distribution. Stable cholesterol cyclic disulphides – tethers for model membranes, were synthesized. New cholesterol markers for research of artificial membranes were designed.

Grantor dc:publisher

Institutional Repository of Vilnius University

Year dc:date

2015

Author dc:creator

• Charkova, Tatjana,

Contributors dc:contributor

• Eicher-Lorka, Olegas

• oligoethylene oxides ; self-assembled monolayers ; model membranes ; cholesterol markers

Statement dc:rights

• info:eu-repo/semantics/openAccess

Language dc:language

lit

Repository record dc:identifier

https://repository.vu.lt/VU:ELABAETD13940473&prefLang=en_US

OAI identifier oai:identifier

oai:vu.lt:elaba:13940473