The Influence of Sustained CB1 Blockade During Adolescence on Breakpoints in a Progressive-ratio Paradigm

The developmental psychopharmacology of cannabinoids is poorly understood and little is known about the developmental consequences of repeated exposure to cannabinoid antagonists. In these experiments, male Long-Evans rats were treated with SR141716A, a cannabinoid antagonist, throughout adolescence and allowed unrestricted access to food. Control groups were treated with vehicle during the same developmental period and allowed either unrestricted access to food or were pair-fed with a member of the SR-treated group. Motivation to work for food was measured in progressive-ratio sessions at varying levels of food deprivation. For rats that consumed fewer calories throughout adolescence, whether because of pharmacological intervention or food-restriction, motivation was not significantly related to the level of food deprivation. Additionally, the SR-treated group ate more of a novel, palatable food than the vehicle-treated group. Finally, the SR-treated group was generally more motivated to work for food than the pair-fed group, irrespective of the level of deprivation.

Name thesis:degree_name

Master of Science

Level thesis:degree_level

Thesis

Discipline thesis:degree_discipline

Pharmacology & Toxicology

Year dc:date.available

2006

Author dc:creator

• Wright, Mayo Jerry, Jr.

Contributors dc:contributor

• Dr. Jenny L. Wiley
• Dr. Joseph H. Porter

• food consumption
• cannabinoid
• appetite
• adolescent
• motivation
• Medical Pharmacology
• Medical Sciences
• Medicine and Health Sciences

Statement dc:rights

• © The Author

Identifier

https://scholarscompass.vcu.edu/etd/1490

OAI identifier oai:identifier

oai:scholarscompass.vcu.edu:etd-2489