Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 161 for “"cannabinoid"”.
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Synthesis of fluorinated cannabinoid derivatives; Towards PET radiotracers for imaging the cannabinoid receptor
Efforts toward understanding the endocannabinoid system, which is comprised of cannabinoid receptors and endogenous ligands, have rapidly expanded in recent years. The endocannabinoid system can modulate the activity of other neurotransmitters through the type 1 cannabinoid receptor (CB1R) which is …
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Cannabinoid Modulation Of Cisplatin Induced Neuropathy
Endocannabinoid modulation of cancer-related pain is well-documented. Sativex, a cannabinoid extract with a 1:1 ratio of tetrahydrocannabinol (thc) and cannabidiol (cbd) has been shown to alleviate neuropathic pain associated with chemotherapy. This research examined whether thc or cbd alone is …
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Optimization and Development of In Vitro Bioassays to Determine Structure-Activity Relationships for Cannabinoid Receptor 1 and Cannabinoid Receptor 2
… Cannabis sativa with approximately 100 being cannabinoids. Of those 100 compounds, Δ9-THC has been determined as the primary constituent, which is also responsible for the psychoactivity associated with Cannabis. Along with Δ9-THC, cannabidiol has been studied in depth for its therapeutic …
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HISTAMINERGIC H3 AND CANNABINOID CB1 RECEPTORS IN DEMENTIA
… therapeutic roles of Histaminergic H3 and Cannabinoid CB1 receptors in neurodegenerative diseases. Based on neurochemical investigations in postmortem human brain samples, the status of H3 receptors remain unchanged under vascular dementia or mixed dementia pathology, and may serve as a …
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Pain-modulating effects of peripheral (CB2) cannabinoid receptors
Cannabinoid receptor agonists diminish responses to painful stimuli. Extensive evidence implicates the CB1, receptor in the production of antinociception, inflammatory hyperalgesia, and peripheral nerve injury-induced sensory hypersensitivity. In previous work included in my masters thesis, our …
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Central cannabinoid regulation of food intake in chickens
… of the antimarijuana attitude, research with cannabinoids was neglected for a long time. Although this substance is related to social problems, scientists are interested in its action and possible medicinal properties. Since the identification of the structure of Î 9--tetrahydrocannabinol, the …
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Design, Synthesis and Biological Evaluation of Novel Cannabinoid Antagonist
… study was aimed at the development of novel CB1 cannabinoid receptor antagonists that may have clinical applications for the treatment of cannabinoid and psychostimulant addiction. The rationale for the design for our target was to incorporate a bioisosteric 1,2,3-triazole ring into the vicinal …
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CANNABINOID RECEPTORS (CB) IN COCHLEA: CHARACTERIZATION AND OTOPROTECTIVE FUNCTIONS
Endocannabinoid (eCB) system is composed of endogenous CB ligands including anandamide (AEA) and 2-Arachidonyl glycerol (2-AG), enzymes involved in their biosynthesis and degradation such as diacylglycerol lipase-α (DAGL- α), and CB receptors. Primarily, there are three types of CB receptors - CB …
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Design, Synthesis And Cannabinoid Receptor Activity Of Benzofuran Ligands
The endocannabinoid system is a complex homeostatic signaling system controlled through the actions of two g-protein coupled receptors, cannabinoid receptor 1 (cb1) and cannabinoid receptor 2 (cb2). Significant neuronal expression and distribution of cb1 throughout the brain establishes its …
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Role of Type 2 Cannabinoid Receptor (CB2) in Atherosclerosis.
… influence lesion development in atherosclerosis. Cannabinoids, compounds structurally related to Δ<sup>9</sup>-tetrahydrocannabinol (THC), the active ingredient in marijuana, exert their effects through cannabinoid receptors, CB1 and CB2. Cannabinoid treatment, THC or Win55,212-2, reduces …
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Cannabinoid regulation of excitatory synaptic transmission at hippocampal synapses
Cannabinoids have recently received significant attention, due to the important functional role of the endocannabinoid system in modulating brain function. Indeed, increasing public and media interest has focused on the therapeutic potential of cannabinoids in treating a variety of CNS-driven …
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Molecular mechanism of ligand induced regulation of cannabinoid receptors
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2025-12-01
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Cannabinoid Modulation of Chemotaxis of Macrophages and Macrophage-like Cells
Exogenous and endogenous cannabinoids have been reported to modulate functional activities of macrophages. It is recognized that macrophages express primarily the CB2 cannabinoid receptor, but recent studies indicate that its expression is differential in relation to activation state with maximal …
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Crafting Cannabinoid Capitalism: Health, Sustainability, and Regeneration in the United States
This dissertation offers a critical exploration of cannabis legalization through an ethnographic study of small-scale "legacy" cannabis farmers in Humboldt County, California, as they navigate a complex transition from prohibition to commodity capitalism. I focus on their collective efforts to …
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Renal Cannabinoid Receptor Expression and Function: Their Role in Obesity and Diabetes
… and diabetic associated renal damage. The endocannabinoid system is an important endogenous lipid signalling system known to mediate glucose and lipid metabolism, inflammation and energy storage. Specifically, diabetes mellitus and obesity induces alterations in the expression of cannabinoid …
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Synthesis of Amphibian Alkaloids and Synthesis and Affinity of Novel Cannabinoid Receptor Ligands
… and good overall yield. The search for potent cannabinoid receptor partial agonist ligands as potential marijuana addiction therapeutic agents has led to an investigation of the synthesis of diaryl ether hybrid analogues of BAY 59-3074. A series of 2-(3-alkyl-5-hydroxyphenoxy)-6- …
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Cannabinoid CB1R Receptor Mediates Metabolic Syndrome in Models of Circadian and Glucocorticoid Dysregulation
… to increase the production and release of endocannabinoid molecules. Additionally, endocannabinoids are potent regulators of appetite, energy balance and metabolic processes through both central and peripheral regulation of feeding and metabolism, making the system an ideal candidate. Mice …
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Fungi-derived natural products with binding affinities for human opioid or cannabinoid receptors
Both opioid and cannabinoid receptors belong to the large superfamily of GPCRs and play an important role in a variety of processes including pain, craving, neurodegeneration, metabolic regulation, anxiety and immune function. Therefore, recent advances and discoveries in opioid and cannabinoid …
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