Electrospun Blends of Polydioxanone and Fibrinogen for Urological Applications

The need for tissue and organ replacements cannot be satisfied by autograft and allografts alone. The purpose of this study was to investigate the feasibility of electrospinning a blend of polydioxanone and fibrinogen to produce an engineered tissue scaffold. Fiber diameter and pore size of blends were characterized, as well as mechanical strength. Cell proliferation assays for 1 and 7 day cultures were preformed, and a histological evaluation was performed to determine how favorable the various blends were to cell infiltration and proliferation. Some ratios of blends were identified that contained both acceptable mechanical properties and properties that facilitated cell infiltration. These findings pave the way for future refinement and use of these scaffolds for a variety of tissue engineered targets.

Name thesis:degree_name

Master of Science

Level thesis:degree_level

Thesis

Discipline thesis:degree_discipline

Physiology

Year dc:date.available

2007

Author dc:creator

• Grant, Joshua Ford

Contributors dc:contributor

• Dr. Gary L. Bowlin

• electrospin
• urology
• tissue engineering
• polydioxanone
• fibrinogen
• Life Sciences
• Physiology

Statement dc:rights

• © The Author

Identifier

https://scholarscompass.vcu.edu/etd/891

OAI identifier oai:identifier

oai:scholarscompass.vcu.edu:etd-1890