Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 158 for “"fibrinogen"”.
-
Viscoelastic haemostatic assays and fibrinogen concentration tests during haemodilution: The effects of fibrinogen and factor XIII
Background: The efficacy of concentrates of fibrinogen and factor XIII in hypothermia and haemodilution has not yet been completely investigated. Clauss methods have not previously been evaluated perioperatively. Methods: Coagulation was assessed with rotational thromboelastometry (ROTEM) or free …
-
Electrospun Blends of Polydioxanone and Fibrinogen for Urological Applications
… of electrospinning a blend of polydioxanone and fibrinogen to produce an engineered tissue scaffold. Fiber diameter and pore size of blends were characterized, as well as mechanical strength. Cell proliferation assays for 1 and 7 day cultures were preformed, and a histological evaluation was …
-
Conceptus-derived Fibrinogen and its Implication in Equine Pregnancy
… Throughout mobility, the conceptus secretes fibrinogen (an integrin-binding ECM). We hypothesized that conceptus-derived fibrinogen is converted into fibrin and aids in fixation via integrin receptors. We determined that RGD-binding integrins are expressed in endometrial and embryonic/fetal …
-
Autologous Fibrinogen Purification and Concentration For Use in Fibrin Sealant
<p>Fibrinogen concentrates are used widely as a sealant during and after surgery to reduce blood loss. Commercially available fibrin sealants are made from pooled human blood, which carries the risk of blood-borne diseases, and are expensive. These concerns have brought to focus the need for …
-
Characterisation of fibrinogen and fibrin proteolysis by the neutrophil membrane
… membrane associated protease which degrades fibrinogen, fibrin and C-reactive protein (CRP) during incubation of these ligands with phorbol 12-myristate 13-acetate (PMA, 5-10 ng/ml) stimulated neutrophils. This proteolysis is predominantly an extracellular event which occurs through a ligand …
-
Towards Establishing Methods of Synthesis, Purification, and Structural Determination for Human Fibrinogen
Fibrinogen is a prevalent blood-based glycoprotein. In its polymerizable form, fibrin, it serves as the structural component of blood clots and helps to incorporate red blood cells, macrophages, and fibroblasts to the wound-site. Fibrinogen plays important roles in inflammation and tissue …
-
DNA Methylation Landscape of the Fibrinogen Gene Cluster in the Equine Embryo
… period the equine embryo expresses and secretes fibrinogen, a protein best known for its involvement in the coagulation cascade and wound repair. The aim of this MSc project was to contribute to the characterization of conceptus-derived fibrinogen at the time of fixation. We confirmed early …
-
Production and Secretion of Recombinant Human Fibrinogen by the Transgenic Murine Mammary Gland
… and the three cDNAs coding for the Aα, Bβ and γ fibrinogen chains to evaluate the requirements of the transgenic murine mammary gland for high level secretion of fully assembled human fibrinogen. After introducing the constructs into the murine zygotes by microinjection, secretion of fully …
-
Scaffold Permeability as a Means to Determine Fiber Diameter and Pore Size of Electrospun Fibrinogen
… the hydraulic permeability of electrospun fibrinogen scaffolds, providing insight into the transport properties of electrospun scaffolds while making the measurement of their topographical features (fiber and pore size) more accurate. Three different concentrations of fibrinogen were used …
-
Incorporation of Tetracycline Hydrochloride into Electrospun Fibrinogen: a study of mechanical properties and time release
… a habitable environment for cell proliferation. Fibrinogen is a natural protein capable of being electrospun and offers the benefit of existing as part of the natural coagulation cascade. Mats of fibrinogen could be utilized as possible hemostatic dressings or as an early scaffold for cell …
-
Validation of TEG5000 Functional Fibrinogen Reagent as Abnormal Quality Control Material for TEG 6s PlateletMapping
… covers the validation process of the Functional Fibrinogen reagent as an abnormal quality control material for platelet mapping using Thromboelastograph (TEG) 6s hemostatic analyzer at NorthBay Medical Center Clinical Laboratory. The Functional Fibrinogen reagent was manufactured for TEG 5000, …
-
Correlation of Homocysteine Concentration with Plasma Fibrinogen and Physical Activity in Males with Coronary Artery Disease
… but not consistently, been demonstrated. Plasma fibrinogen and total Hcy concentrations, along with other risk factors, folate and Bvitamin supplements, and medications, were recorded for 40 males (mean age ± SD: 65 ± 9.8 yr) with CAD. Physical activity was assessed using the Modifiable Activity …
-
A neutral protease of the neutrophil surface : role in the proteolysis of C-reactive protein and fibrinogen
… acute phase reactants, C-reactive protein and fibrinogen, as well as neutrophils have been shown to accumulate at sites of tissue injury or inflammation. The association of C-reactive protein with neutrophils and the concomitant degradation of this ligand by a phorbol 12-myristate 13 …
-
Periodontal Healing of Canine Experimental Grade III Furcation Defects Treated With Autologous Fibrinogen and Resolut® Barrier Membrane
… alone, or with the addition of autologous fibrinogen, Resolut® barrier membrane, or autologous fibrinogen and Resolut® barrier membrane. The defects were analyzed by digital subtraction radiography, histopathologic, and histomorphometric analysis of healing at 1, 3, and 6 months …
-
A New Role for Beta-Amyloid in Alzheimer's Disease: Initiation of Thrombotic and Inflammatory Processes Via Coagulation Factor XII and Fibrinogen
… I also defined the regions involved in Aβ-fibrinogen binding and elucidated the mechanism by which this interaction results in delayed fibrinolysis. My results suggest new pathogenic mechanisms, diagnostic tests, and therapeutic targets for AD.</p>
-
An investigation into the effect of oxLDL and cyclic nucleotides on platelet cytoskeletal function
… shown that platelets bind effectively to fibrinogen, but that this can be reversed by prostacyclin (PGI2). We now demonstrate that the combination of fibrinogen and oxLDL as a matrix protein induced a significant increase in platelet adhesion and spreading in a dose-dependent manner. …
-
Single Fibrin Fiber Mechanical Properties and Lysis
Fibrinogen, one of the most abundant proteins in blood plasma, plays a central role in hemostasis and thrombotic disease. In the final step of the coagulation cascade, thrombin proteolytically converts fibrinogen to fibrin, which then forms a mesh of fibrin fibers. This mesh is the major structural …
Page 1 of 8