The role of genetic factors and lifestyle relationship to obesity and metabolic syndrome in a sample of Bulgarian population // Проучване ролята на генетични фактори и начина на живот за изявата на затлъстяване и метаболитен синдром в извадка от българската популация

[EN] The dissertation work was dedicated to obesity – serious problem of high medical and social significance of our time widespread all over the world. Certain genetic risk factors for obesity and metabolic syndrome and related biochemical and clinical parameters were studied and evaluated. The allele frequencies of four genes by selected single nucleotide polymorphisms were investigated in a sample of Bulgarian population and compared to the same polymorphisms in different populations. A demographic and social characteristics of the respondents was assessed. A pilot study research for cost-effective and safe approaches for prevention and treatment of obesity and related metabolic disorders was provided. Therefore the anti-inflammatory activity of the medicinal plant Agrimonia eupatoria (agrimony) was studied. On the basis of the studies that scientific work has shown that obesity had polygenic nature. Carriage of a particular genotype may determine predisposition, but social factors determine the obesity phenotype. Higher education level, female sex, younger age and employment were positively correlated with healthy weight. It was found that an aqueous extract of Agrimonia eupatoria had increased antioxidant capacity of blood plasma in humans and had reduced the concentration of certain inflammatory proteins. Today it’s known that obesity is a condition accompanied by oxidative stress, and low-grade chronic inflammation. Hence it might be expected that the medicinal plant agrimony would have a beneficial effect in preventing and treating obesity-related metabolic disorders.

Authors dc:creator

• Vankova, Deyana
• Ванкова, Деяна

• obesity
• genetic factors
• metabolic syndrome
• Agrimonia eupatoria L
• Биохимия, молекулна медицина и нутригеномика​ / Biochemistry, Molecular Medicine, Nutrigenomics

Repository record dc:identifier

http://repository.mu-varna.bg/handle/nls/58

OAI identifier oai:identifier

oai:repository.mu-varna.bg:nls/58