Apoptosis and Necroptosis in Basal Cell and Spinocellular Carcinoma of the Skin // Апоптоза и некроптоза при базоцелуларен и спиноцелуларен карцином на кожа

Skin carcinomas originating in the epidermis are of two main histological types: basal cell carcinoma (BCC) and spinocellular or squamous cell carcinoma (SCC). Since 2000, Bulgaria has seen a steady increase in the incidence and mortality of these neoplasms. Apoptosis is a process of programmed cell death. Disruptions in the process of apoptosis are considered one of the main causes of neoplastic processes. Caspase-3 is one of the most important molecules in the apoptotic cascade, often used to monitor the efficacy of malignant neoplasm treatment. Necroptosis is a type of cell death that has features of both apoptosis and necrosis. RIPK3 is a major necrotic protein in various types of neoplasms. In the process of eliminating and destroying tumour cells, the mechanisms and pathways of different types of cell death can be involved in complex interactions. Therapeutic approaches include surgery, targeted therapy, radiation, and chemotherapy, leading to the induction of apoptosis, a natural process of programmed cell death that eliminates tumour cells. If apoptosis cannot be induced, alternative pathways for cell death must be sought. This study aims to investigate the immunohistochemical expression of the apoptosis marker Caspase-3 and the necroptosis marker RIPK3 in patients with basal cell and squamous cell carcinoma of the skin and to determine their predictive value.

Grantor dc:publisher

Medical University of Varna

Year dc:date

2025

Authors dc:creator

• Vasilev, Plamen
• Василев, Пламен

• skin carcinoma, spinocellular, squamous cell carcinoma, necroptosis
• Патологоанатомия и цитопатология / Pathological anatomy and cytopathology

Repository record dc:identifier

http://repository.mu-varna.bg/handle/nls/4254

OAI identifier oai:identifier

oai:repository.mu-varna.bg:nls/4254