Research on the Participation of Humoral Factors of Congenital Immunity in the Pathogenesis of Activated Osteoarthritis // Изследване участието на хуморалните фактори на вродения имунитет в патогенезата на активираната остеоартроза

The thesis examines the role of humoral factors of innate immunity in the pathogenesis of activated osteoarthritis (OA) of the knee joint. Data from numerous studies indicate that the question of whether the complement cascade plays a role solely as a cleansing system or also as a leading pathogenic factor in activated OA remains unanswered in science. The participants in the study are 156 patients with OA of the knee joint according to the ACR criteria from 1991. Levels of CRP, C3, and C4 complement fractions are examined in blood plasma and synovial fluid. Statistical analysis of the collected data shows that the average percentage of CRP levels in synovial fluid is 42.14% of plasma levels, higher than the normal 20%. The average percentages of C3 and C4 levels in synovial fluid are 34.90% and 30.97% of plasma levels, above the normal 10% for both C3 and C4. In other words, the average percentages of all three indicators in synovial fluid in activated gonarthrosis are significantly higher than those in blood plasma. The conclusions of the study emphasise the significant role of CRP and the complement system as humoral factors of innate immunity in the pathogenesis of activated OA of the knee joint. The results argue for the application of drugs affecting low-grade inflammation as a disease-modifying treatment model and confirm the need for therapeutic control of inflammation in the arthritic joint at an early radiological stage of the disease.

Grantor dc:publisher

Medical University of Varna

Year dc:date

2024

Authors dc:creator

• Momcheva, Irina
• Момчева, Ирина

• osteoarthritis
• knee joint
• synovial fluid
• inflammation
• Oбща медицина / General Medicine

Repository record dc:identifier

http://repository.mu-varna.bg/handle/nls/3768

OAI identifier oai:identifier

oai:repository.mu-varna.bg:nls/3768