Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 33 for “"The complement system"”.
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The Role of the Complement System in Mousepox Infection
Poxviruses subvert the host immune response by producing immunomodulatory virulence factors, including a complement regulatory protein. Ectromelia virus provides a mouse model for human smallpox infection where the virus and the host's immune response have also co-evolved. Using this model, we …
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Studies of EHEC and the complement system in renal diseases
This thesis addressed the diagnosis, pathogenesis and clinical course of specific renal diseases hemolytic uremic syndrome (HUS) and dense deposit disease (DDD). HUS may be associated with infection caused by Enterohemorrhagic Escherichia coli (EHEC) or with complement dysfunction due to complement …
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Molecular Interactions of Human C9: The Pore Forming Protein of the Complement System
<p>The human complement system is part of our innate immunity that acts to eliminate pathogenic organisms. Activation of complement leads to the sequential, non-enzymatic assembly of C5b, C6, C7, C8, C9 forming C5b-9<sub>n</sub> (n=12-18), a cytolytically active pore-like structure known as the …
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Genetic, molecular and functional analyses of factor I - an inhibitor of the complement system
Factor I (FI) is a serine protease that inhibits the complement system by cleaving activated C3 and C4 complement proteins, in the presence of cofactors. Mutations in the gene coding for FI have been identified in complete FI deficient- and atypical hemolytic uremic syndrome (aHUS) patients. The …
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Interaction Between the Metalloprotease ADAMTS-13 and the Proteins of the Alternative Pathway of the Complement System
… in hemostasis, has been shown to interact with complement components. However results are contrasting and inconclusive. By studying 20 patients with congenital thrombotic thrombocytopenic purpura (cTTP) who can not cleave VWF multimers due to genetic ADAMTS13 deficiency, we investigated the …
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Investigating the role of the complement system in the pathogenesis of sub-retinal fibrosis in neovascular age related macular degeneration
Age related Macular Degeneration (AMD) is the leading cause of blindness in the elderly population of developed countries. Advanced AMD is categorised into two subtypes, “dry” AMD and “wet” or neovascular AMD (nAMD). nAMD is characterised by choroidal neovascularisation (CNV), which is the growth …
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Survival strategies of the human respiratory tract pathogen Haemophilus influenzae
… one of six serotypes (a-f), of which type b is the most virulent one causing serious and sometimes life-threatening diseases (e.g., epiglottitis, septicaemia and meningitis). In contrast, non-typeable H. influenzae (NTHi) accounts for the majority of local and upper and lower respiratory tract …
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On the immunopathogenesis of systemic lupus erythematosus - Immune complexes, type I interferon system, complement system and platelets
Systemic lupus erythematosus (SLE) is an autoimmune rheumatic disorder characterized by inflammation in several organ systems. SLE patients have an impaired ability to clear dying cells which leads to the exposure of several nuclear antigens which might break self tolerance. Autoantibodies directed …
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Multivariate Statistical Analysis In Single Cell Transcriptomics
With technological advances in the last decade, single cell RNA sequencing (scRNAseq) has emerged as an exciting weapon in the modern scientist’s arsenal to unravel cellular heterogeneity. The ability to measure the transcriptome in each individual cell in any given tissue poses challenges galore, …
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Interaction of Bacillus Anthracis Exosporium Protein Bcla With Complement Factor H and Spore Persistence In The Lung
<p>Anthrax outbreaks in the United States and Europe and its potential use as a bioweapon have made <em>Bacillus anthracis</em> an interest of study. Anthrax infections are caused by the entry of <em>B. anthracis</em> spores into the host via the respiratory system, the gastrointestinal tract, cuts …
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Die Untersuchung zellulärer inflammatorischer Prozesse bei Pseudoxanthoma elasticum
The autosomal-recessive disorder Pseudoxanthoma elasticum (PXE) is characterized by progressive calcification and fragmentation of elastic fibers. The cause of PXE are mutations in the gene ATP-binding cassette subfamily C member 6 (ABCC6), encoding ABCC6, an ATP-binding transport protein. Further …
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Screening and Functional Analysis of New Anti-Complement Autoantibodies in the Course of Systemic Lupus Erythematosus // Скрининг и функционален анализ на нови анти-комплементни автоантитела в хода на системен лупус еритематодес
The role of autoimmunity and the loss of immune tolerance to own proteins have a significant place in the current ideas about the aetiology and pathogenesis of systemic lupus erythematosus (SLE). The disease is characterized by broad-spectrum organ manifestations, multiple autoantibodies and …
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Probabilistic Approximation and Analysis Techniques for Bio-Pathway Models
… modeling of bio-pathway dynamics is crucial to the system-level understanding of cellular functions and behavior. Currently, a common method of representing bio-pathways is through a system of ordinary differential equations (ODEs). However, calibrating and analyzing large ODE-based pathway …
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The role of anaphylatoxins in asthma and airway remodelling
… are proinflammatory polypeptides released during complement activation. They exert their biological functions by interacting with the G protein-coupled receptors, C3aR and C5aR respectively. Activation of the complement system has been implicated in the pathogenesis of many inflammatory diseases …
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Research on the Participation of Humoral Factors of Congenital Immunity in the Pathogenesis of Activated Osteoarthritis // Изследване участието на хуморалните фактори на вродения имунитет в патогенезата на активираната остеоартроза
The thesis examines the role of humoral factors of innate immunity in the pathogenesis of activated osteoarthritis (OA) of the knee joint. Data from numerous studies indicate that the question of whether the complement cascade plays a role solely as a cleansing system or also as a leading …
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THE ROLE OF BACTERIAL AMYLOID FIBRILS IN ESCHERICHIA COLI COMPLEMENT RESISTANCE
… capable of causing morbidity and mortality. Of the E. coli which causes human disease, many strains which cause bacteremia have been identified as possessing virulence factors which make them more resistant to the complement system. The bacterial amyloid fibril, curli, functions in bacterial …
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Characterization of Complement C3 Dysregulation Predisposing to Two Human Disease States
The complement system is an essential branch of the innate immune system and acts as a bridge to the adaptive immune system. It serves as the first line of defense against pathogens, as well as in the clearance of immune complexes and apoptotic cells. Deficiencies in many of the complement …
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Genetic Factors Associated with Anti-Factor H Autoantibodies in Atypical Hemolytic Uremic Syndrome (aHUS)
… acquired defects of alternative pathway (AP) of the complement system. Autoantibodies against factor H (anti-FHs), a regulator of the AP, were reported in 10% of patients, and are associated with the deficiency of factor H related 1 (FHR1), a FH homologous protein. <br></br><br></br> The aim of …
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Novel Endogenous Antimicrobial Peptides
… are an essential part of our fast innate immune system. They are ancient molecules found in all classes of life. Antimicrobial peptides rapidly kill a broad spectrum of microbes and are immunomodulatory, i.e. having additional actions influencing inflammation and other innate immune responses. …
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Aspects of retransfusion of shed blood in cardiac surgery
The use of cardiotomy suction during open heart surgery with cardiopulmonary bypass (CPB) has a long tradition and often regarded as mandatory. Recently, studies have described potentially negative effects of cardiotomy suction with activation of the complement system, enhanced inflammatory …
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