Synthesis, Structure and Properties of New Iodine Derivatives of Natural Aromatic Acids // Синтез, структура и свойства на нови йодопроизводни на природни ароматни киселини

Iodination reactions of organic substrates are one of the most significant chemical transformations in pharmaceutical synthesis. No less important are the reactions that use the already obtained iodine-substituted compounds for the synthesis of much more complex ones. In addition, in view of the apparent deficiency of iodine-containing contrast agents, the synthesis of new organoiodic compounds is extremely valuable and significant. Syntheses have been carried out, and the structural features and biological properties of a series of new organoiodic substances have been studied. Their potential in the synthesis of other substances has also been assessed. The dissertation examines the preparation and characterization of a new organoiodic compound - 2,6-diiodo-3,4,5-trimethoxybenzoic acid (DITMBA). Its unique spectral behaviour has been established, as well as the optimal reaction conditions allowing the synthesis of DITMBA in maximum yield (≥98%) and extremely high (≥99%) purity. The co-crystallizing ability of DITMBA against four N-containing pharmacopoeial agents was determined. Two new meta-terphenyl derivatives with a central 3,4,5-trimethoxybenzoic carboxyl motif were synthesized.

Grantor dc:publisher

Medical University of Varna

Year dc:date

2022

Authors dc:creator

• Hadzhieva, Nadya
• Хаджиева, Надя

• iodination
• pharmaceutical synthesis
• iodine-substituted compounds
• organoiodic compounds
• Химия / Chemistry

Repository record dc:identifier

http://repository.mu-varna.bg/handle/nls/2464

OAI identifier oai:identifier

oai:repository.mu-varna.bg:nls/2464