An Investigation of the Clinical Predictors of Impulse Control Disorders in Patients with Parkinson's Disease

A sub-group of patients with Parkinson’s disease (PD) experience impulse control disorders (ICD), which can result in serious negative consequences. Although clarifying the risk factors of ICD can inform tailored intervention strategies, the clinical predictors of ICD are poorly understood. The present study provides a longitudinal analysis of clinical predictors of ICD using three groups of de novo patients with PD that were established from the Parkinson’s Progression Markers Initiative: Patients with ICD present at Baseline (n = 114), patients who develop ICD (n = 126), and patients with no ICD or related behaviours (n = 97). Bayesian and Frequentist analyses demonstrated that Anxiety predicts the development of ICD. Depression, Excessive Daytime Sleepiness (EDS), and REM Sleep Behaviour Disorder (RBD) Symptoms were increased among patients with ICD compared to those without. Assessment of Anxiety, Depression, EDS, and RBD Symptoms should be incorporated into ICD intervention strategies for patients with PD.

Name thesis:degree_name

M Sc

Discipline thesis:degree_discipline

Neuroscience

Grantor dc:publisher

The University of Western Ontario

Year dc:date.issued

2025

Author dc:creator

• Breddy, Taylor N.

Advisor dc:contributor.advisor

• MacDonald, Penny A.

• Parkinson’s disease
• Impulse control disorder
• Anxiety
• Depression
• Excessive daytime sleepiness
• REM sleep behaviour disorder

Statement dc:rights

• Attribution-ShareAlike 4.0 International

Language dc:language.iso

en

Handle dc:identifier.uri

https://hdl.handle.net/20.500.14721/38403

OAI identifier oai:identifier

oai:uwo.scholaris.ca:20.500.14721/38403