The Characterization of Hemodialysis Membranes in Miniaturized Dialyzers

Lack of an appropriate animal model prevents rapid evaluation of health outcomes associated with hemodialysis. We developed a miniaturized dialyzer for use in small rats. The aim of this study was to investigate whether the miniaturized dialyzers can differentiate performance characteristics representing hemodialysis membrane and fiber design. We evaluated internal filtration, water permeability, sieving coefficient (SC) and clearance of solutes, in the Medium Cut Off (MCO) and conventional High Flux (HF) miniaturized dialyzers. We found statistically significant differences between miniaturized MCO and conventional HF dialyzers with respect to ultrafiltration coefficient, clearance of Beta-2 Microglobulin (B2M), and SC of B2M.These outcomes suggest that the miniaturized dialyzers can effectively differentiate performance characteristics representing hemodialysis membrane and fiber design. This indicates that the miniaturized dialyzers are an appropriate component of a pre- clinical pipeline of dialysis technology impact.

Name thesis:degree_name

M Sc

Discipline thesis:degree_discipline

Medical Biophysics

Grantor dc:publisher

The University of Western Ontario

Year dc:date.issued

2023

Author dc:creator

• Moradshahi, Mehrshad

Advisor dc:contributor.advisor

• McIntyre, Christopher

• Medium Cut Off (MCO)
• High Flux (HF)
• Miniaturized Dialyzer
• Hemodialysis
• Beta-2 Microglobulin (B2M)

Language dc:language.iso

en_ca

Handle dc:identifier.uri

https://hdl.handle.net/20.500.14721/32765

OAI identifier oai:identifier

oai:uwo.scholaris.ca:20.500.14721/32765