{"id":{"repo_id":"uwo","oai_identifier":"oai:uwo.scholaris.ca:20.500.14721/32765"},"canonical_url":"https://search.dev.ndltd.org/etd/uwo/oai:uwo.scholaris.ca:20.500.14721/32765","repository":{"repo_id":"uwo","name":"Western University","base_url":"https://uwo.scholaris.ca/server/oai/request"},"display":{"title":"The Characterization of Hemodialysis Membranes in Miniaturized Dialyzers","abstract":"Lack of an appropriate animal model prevents rapid evaluation of health outcomes associated with hemodialysis. We developed a miniaturized dialyzer for use in small rats. The aim of this study was to investigate whether the miniaturized dialyzers can differentiate performance characteristics representing hemodialysis membrane and fiber design. We evaluated internal filtration, water permeability, sieving coefficient (SC) and clearance of solutes, in the Medium Cut Off (MCO) and conventional High Flux (HF) miniaturized dialyzers. We found statistically significant differences between miniaturized MCO and conventional HF dialyzers with respect to ultrafiltration coefficient, clearance of Beta-2 Microglobulin (B2M), and SC of B2M.These outcomes suggest that the miniaturized dialyzers can effectively differentiate performance characteristics representing hemodialysis membrane and fiber design. This indicates that the miniaturized dialyzers are an appropriate component of a pre- clinical pipeline of dialysis technology impact.","abstract_html":"Lack of an appropriate animal model prevents rapid evaluation of health outcomes associated with hemodialysis. We developed a miniaturized dialyzer for use in small rats. The aim of this study was to investigate whether the miniaturized dialyzers can differentiate performance characteristics representing hemodialysis membrane and fiber design. We evaluated internal filtration, water permeability, sieving coefficient (SC) and clearance of solutes, in the Medium Cut Off (MCO) and conventional High Flux (HF) miniaturized dialyzers. We found statistically significant differences between miniaturized MCO and conventional HF dialyzers with respect to ultrafiltration coefficient, clearance of Beta-2 Microglobulin (B2M), and SC of B2M.These outcomes suggest that the miniaturized dialyzers can effectively differentiate performance characteristics representing hemodialysis membrane and fiber design. This indicates that the miniaturized dialyzers are an appropriate component of a pre- clinical pipeline of dialysis technology impact.","abstract_has_math":false,"creators":["Moradshahi, Mehrshad"],"institution":"The University of Western Ontario","degree_name":"M Sc","degree_level":null,"degree_discipline":"Medical Biophysics","degree_department":null,"school":null,"contributors":[],"advisors":["McIntyre, Christopher"],"committee_chairs":[],"committee_members":[],"year":2023,"date_issued":"2023-01-18","date_published":"2023-01-18","updated_at":"2026-07-27T21:56:05Z","subjects":["Medium Cut Off (MCO)","High Flux (HF)","Miniaturized Dialyzer","Hemodialysis","Beta-2 Microglobulin (B2M)"],"languages":["en_ca"],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"https://hdl.handle.net/20.500.14721/32765","outbound_label":"Handle","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor.advisor","label":"Advisor","values":["McIntyre, Christopher"]},{"key":"dc:creator","label":"Author","values":["Moradshahi, Mehrshad"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2025-07-10T19:36:18Z"]},{"key":"dc:date.available","label":"Dc Date Available","values":["2025-07-10T19:36:18Z"]},{"key":"dc:date.issued","label":"Date","values":["2023-01-18"]},{"key":"dc:publisher","label":"Institution","values":["The University of Western Ontario"]},{"key":"dc:type","label":"Dc Type","values":["thesis"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Medical Biophysics"]},{"key":"thesis:degree_name","label":"Degree Name","values":["M Sc"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Medium Cut Off (MCO)","High Flux (HF)","Miniaturized Dialyzer","Hemodialysis","Beta-2 Microglobulin (B2M)"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language.iso","label":"Language (ISO)","values":["en_ca"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.uri","label":"Identifier URI","values":["https://hdl.handle.net/20.500.14721/32765"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["The thesis cover page in the PDF document includes references to Western University’s previous institutional repository platform, known as Scholarship@Western, and links to that platform (beginning with ir.lib.uwo.ca). In citing or referring to this thesis, use the DOI or handle from this page instead. Sample citation: Author name, \"Thesis title.\" (Year). Western University Open Repository. https://doi.org/10.71858/123456."]},{"key":"dc:description.abstract","label":"Abstract","values":["Lack of an appropriate animal model prevents rapid evaluation of health outcomes associated with hemodialysis. We developed a miniaturized dialyzer for use in small rats. The aim of this study was to investigate whether the miniaturized dialyzers can differentiate performance characteristics representing hemodialysis membrane and fiber design. We evaluated internal filtration, water permeability, sieving coefficient (SC) and clearance of solutes, in the Medium Cut Off (MCO) and conventional High Flux (HF) miniaturized dialyzers. We found statistically significant differences between miniaturized MCO and conventional HF dialyzers with respect to ultrafiltration coefficient, clearance of Beta-2 Microglobulin (B2M), and SC of B2M.These outcomes suggest that the miniaturized dialyzers can effectively differentiate performance characteristics representing hemodialysis membrane and fiber design. This indicates that the miniaturized dialyzers are an appropriate component of a pre- clinical pipeline of dialysis technology impact."]},{"key":"dc:title","label":"Title","values":["The Characterization of Hemodialysis Membranes in Miniaturized Dialyzers"]}]}],"canonical_facts":{"dc:contributor.advisor":["McIntyre, Christopher"],"dc:creator":["Moradshahi, Mehrshad"],"dc:date.accessioned":["2025-07-10T19:36:18Z"],"dc:date.available":["2025-07-10T19:36:18Z"],"dc:date.issued":["2023-01-18"],"dc:description":["The thesis cover page in the PDF document includes references to Western University’s previous institutional repository platform, known as Scholarship@Western, and links to that platform (beginning with ir.lib.uwo.ca). In citing or referring to this thesis, use the DOI or handle from this page instead. Sample citation: Author name, \"Thesis title.\" (Year). 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We found statistically significant differences between miniaturized MCO and conventional HF dialyzers with respect to ultrafiltration coefficient, clearance of Beta-2 Microglobulin (B2M), and SC of B2M.These outcomes suggest that the miniaturized dialyzers can effectively differentiate performance characteristics representing hemodialysis membrane and fiber design. 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