Breast Cancer Risk For Female Relatives of Male Breast Cancer Patients With Negative Brca1/2 Testing

<p>Risk models exist to estimate a female’s lifetime risk of breast cancer in the absence of a hereditary predisposition to cancer, namely Hereditary Breast and Ovarian Cancer syndrome. These risk models consider various factors such as reproductive history and family history, but few models take a family history of male breast cancer into account. This study aims to evaluate if prevalence of breast cancer among female relatives is higher when there is a family history of male breast cancer in the context of uninformative <em>BRCA1 </em>and <em>BRCA2 </em>testing. This information may aid in the process of risk assessments for patients and their families following uninformative germline genetic testing.</p> <p>A retrospective chart review was performed to compare the family histories of males with breast cancer (the case group) and males with prostate cancer (the comparison group) following uninformative <em>BRCA1 </em>and <em>BRCA2 </em>germline genetic testing. Univariate logistic regression was performed to calculate odds ratios for first- and second-degree relatives with statistical significance assumed at p < 0.05.</p> <p>Our data showed a statistically significant difference in odds ratio for first-degree relatives, however the comparison group may have had a selection bias. There was no statistically significant difference in odds ratios for maternal and paternal second-degree relatives. These results support current clinical recommendations for female relatives of male breast cancer patients following uninformative <em>BRCA1 </em>and <em>BRCA2 </em>testing, however further research is needed to better characterize the risk to female family members of males with breast cancer.</p>

Name thesis:degree_name

Masters of Science (MS)

Level thesis:degree_level

Thesis (MS)

Year dc:date.available

2021

Authors dc:creator

• Martin, Emily
• <p>0000-0003-3857-0562</p>

Contributors dc:contributor

• Chelsea Wagner, MS, CGC
• Rachel Bluebond, MMSc, CGC
• Leslie Dunnington, MS, CGC

• male breast cancer
• BRCA
• familial breast cancer
• risk models
• Congenital, Hereditary, and Neonatal Diseases and Abnormalities
• Genetic Phenomena
• Neoplasms
• Oncology

Repository record dc:identifier

https://digitalcommons.library.tmc.edu/utgsbs_dissertations/1087

OAI identifier oai:identifier

oai:digitalcommons.library.tmc.edu:utgsbs_dissertations-2143