Peripheral Vascular Function in Young Adults with Increased Risk of Cardiometabolic Disease

<p>Objective: To determine if young adults with elevated metabolic syndrome severity scores (MetS_index) suffer from peripheral vasculature dysfunction.</p> <p>Methods: Mean arterial pressure (MAP), Femoral (FBF) and Brachial Blood flow (BBF), Femoral (FVC) and Brachial Vascular Conductance (BVC), and Tissue Saturation Index (TSI) were assessed in twenty-four age (19 + 2.25 years), Sex (male: n=18; female: n=6) and Race (White: n=4; Black/African American: n=4; Asian: n=16) matched individuals during post-occlusive reactive hyperemia (RHBF), passive limb movement (PLM) and Functional Sympatholysis (FS) trials. Carotid femoral pulse wave velocity (cfPWV) was also collected at baseline, and all values were compared between the Control (Con; negative MetS_index score) and Elevated Risk (ER; positive MetS_index score) groups using a combination of independent samples <em>t</em>-tests and repeated measures analyses of variance (RMANOVA).</p> <p>Results: As expected, blood flow and vascular conductance significantly increased during all RHBF and PLM trials across both groups (all p0.591), PLM responses (all p>0.313), brachial RHBF responses (all p>0.132), or FS responses (all p>0.446). Likewise, no group differences were observed for PWV (Con: mean= 5.14 + 1.69m/s; ER: mean= 5.18 + 1.84m/s; p=0.953).</p> <p>Conclusions: The current findings suggest that peripheral vascular function appears to be unaffected in young adults presenting with elevated MetS_index score. Our findings also suggest that MetS_index may provide use as an “early warning” system for young adults at risk of MetS-associated vascular dysfunction and highlights the need for further cardiovascular assessments in these individuals.</p>

Name thesis:degree_name

Master of Science (MS)

Level thesis:degree_level

Masters Thesis

Year dc:date.available

2024

Author dc:creator

• Aultman, Ryan S.

Contributors dc:contributor

• Dr. Jon Stavres
• Dr. Austin Graybeal
• Dr. Stephanie Smith

Repository record dc:identifier

https://aquila.usm.edu/masters_theses/1057

OAI identifier oai:identifier

oai:aquila.usm.edu:masters_theses-2131