Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 46 for “"Vascular Dysfunction"”.
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Prolylcarboxypeptidase protects from vascular dysfunction and promotes vascular repair
… The following studies characterize the vascular phenotype of the PRCP-deficient (PRCPgt/gt) mouse. Compared to wildtype animals, PRCPgt/gt are hypertensive and demonstrate faster times to induced arterial thrombotic occlusion. PRCPgt/gt have increased levels of vascular reactive oxygen …
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Mineralocorticoid receptor involvement in vascular dysfunction associated with vascular injury
… signaling has recently been implicated in cardiovascular dysfunction associated vascular injury. Specifically, MR blockade has been shown to treat coronary microvascular dysfunction in obesity and has been implicated in the regulation of capillary density in ischemic conditions. The fundamental …
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Role of the Haem Oxygenase Pathway in Protection against Vascular Dysfunction
Impairment of vascular function and tissue injury after ischaemic events is a well-known pathophysiological phenomenon. Enhanced oxidative stress by free radicals appears to be a major contributor to the ischaemic episode which can occur either by progression of a disease state (atherosclerosis or …
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Comparison of Leukocyte Classes Most Likely to Cause Vascular Dysfunction in Preeclampsia
… but the class of leukocyte most likely to cause vascular dysfunction is not known. We hypothesized that neutrophils may be the class of leukocyte most involved in causing this dysfunction because neutrophils are the most abundant of the leukocytes and their numbers increase during pregnancy. In …
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Serum Osteoprotegerin, a Potential Novel Marker of Systemic Inflammation: The Influence of Obesity, Insulin Sensitivity and Oral Glucose Loading on its Circulating Concentrations
… the presence of type 2 diabetes, severity of vascular calcification and coronary artery disease. Obesity is a risk factor for diabetes and cardiovascular disease but little is known about the impact of body weight on circulating OPG. The purpose of these experiments was to evaluate the impact …
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Gender differences in aortic endothelial function in a rat model of streptozotocin-induced diabetes : possible role of superoxide and cyclooxygenase
… diabetic women loose their gender based cardiovascular protection. However, there is insufficient evidence to explain the mechanism underlying the loss of this gender based cardioprotection in premenopausal diabetic women. The objectives of this study were to investigate whether there is a …
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The Role of Fractalkine-mediated Neuroprotection in the Diabetic Retina
… neurodegeneration and neuronal loss precedes vascular dysfunction in early diabetes. Inflammation caused by microglia exacerbates retinal pathology. Microglia, the resident immune cells of the central nervous system (CNS), become activated due to hyperglycemia and are believed to contribute to …
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Investigations into endothelial cell permeability and adherens junction disruption induced by Junín virus infection.
… hemorrhagic fever (AHF) characterized by vascular dysfunction and fluid distribution abnormalities. Clinical, as well as experimental studies, have implicated involvement of the endothelium in pathogenesis of AHF, although the role it may play is poorly understood. Junín virus has been …
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Hypoxia and vascular nitric oxide bioavailability: Hypoximplications for the pathophysiology of high-altitude illness
… integral molecule implicated in the control of vascular function. It has been suggested that vascular dysfunction may lead to the development of acute mountain sickness (AMS), high-altitude cerebral oedema (HACE) and high-altitude pulmonary oedema (HAPE), though data to date remains scarce. …
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Obesity as a Risk Factor for Preeclampsia: Role of Inflammation and the Innate Immune System
… NF-κB activation and COX-2 expression in vascular tissue of obese women. We then demonstrated similar neutrophil infiltration and vascular inflammation in preeclamptic women.We used in vitro experiments to test if neutrophils and their products, reactive oxygen species (ROS) and tumor …
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The Effects of Dendro[60]Fullerene on Neurobehavioral Outcome and Cerebral Vascular Function After Traumatic Brain Injury
… oxygen species (ROS) that leads to cerebral vascular dysfunction. The reduction of ROS can preserve vascular function and lead to improved outcomes. The antioxidant carboxyfullerene nanoparticle, dendro[60]fullerene (DF-1) was examined as a potential therapy for TBI because of its strong …
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THE EFFECT OF MELATONIN IN PROTECTING AGAINST THE BEHAVIORAL CONSEQUENCES OF CHRONIC HYPOPERFUSION IN MIDDLE-AGED FEMALE RATS
… portion of time. MCI is often preceded by vascular dysfunction and has the potential to cause irreversible damage to one’s cognitive ability. The neurocognitive consequences of MCI can be imitated through the use of the 2-vessel occlusion (2VO) procedure in rats, which limits cerebral blood …
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The role of FKBPL in diabetes and associated cardiovascular health
… million people living with the condition. Cardiovascular diseases (CVD) are the leading cause of death globally with the incidence three-fold higher in people with diabetes. Furthermore, cardiovascular complication of pregnancy, pre-eclampsia, is also associated with up to four-fold increased …
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Peripheral Vascular Function in Young Adults with Increased Risk of Cardiometabolic Disease
… suffer from peripheral vasculature dysfunction.</p> <p>Methods: Mean arterial pressure (MAP), Femoral (FBF) and Brachial Blood flow (BBF), Femoral (FVC) and Brachial Vascular Conductance (BVC), and Tissue Saturation Index (TSI) were assessed in twenty-four age (19 + 2.25 years), Sex …
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A New Role for Beta-Amyloid in Alzheimer's Disease: Initiation of Thrombotic and Inflammatory Processes Via Coagulation Factor XII and Fibrinogen
… and progression, the mechanisms behind neuronal dysfunction in AD are not completely understood. It is now clear that AD is a complex, multifactorial disease characterized by vascular dysfunction, prothrombotic state, and inflammation, but whether these conditions are a cause or consequence of …
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Effects of nitrite infusion on skeletal muscle vascular control during exercise in rats with chronic heart failure
… (NO) bioavailability and impairs skeletal muscle vascular control during exercise. Reduction of nitrite (NO[subscript]2-) to NO may impact exercise-induced hyperemia particularly in muscles with pathologically-reduced O[subscript]2 delivery. We tested the hypothesis that NO[subscript]2- infusion …
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Arterial Stiffness, Obesity and Metabolic Syndrome in Children and Adolescents
Atherosclerotic cardiovascular disease (CVD) is the leading cause of death in Western Societies. The pathological processes and risk factors associated with its development begin in childhood, long before clinical consequences emerge. Cardiovascular risk factors have been shown to cluster together …
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Blood-Derived Plasminogen Modulates the Neuroimmune Response in Both Alzheimer's Disease and Systemic Infection Models
… arise from genetic or lifestyle factors and that vascular dysfunction and inflammation play a role in the progression of the disease. Many cardiovascular factors associated with an increase in systemic infection have been linked to a risk of AD development and progression. However, the link …
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Mechanisms of HIV-Nef Induced Endothelial Cell Stress: Implications of HIV-Nef Protein Persistence in Aviremic HIV Patients
HIV-associated cardio-pulmonary vascular pathologies such as coronary artery disease, pulmonary hypertension and emphysema remain a major issue in the HIVinfected population even in the era of antiretroviral therapy (ART). The continued production of HIV encoded pro-apoptotic protein, such as Nef …
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