Evaluation of the Protein Recognition Properties of Peptide Nucleic Acids

<p>The objective is to evaluate the ability of aminoacyl-tRNA synthetases (aaRS) to recognize the non-standard nucleic acid, PNA (peptide nucleic acid). PNA has immense potential in biomedical applications due to its increased thermostability and nuclease resistance over natural nucleic acids. PNA represents a superior alternative to natural nucleic acids in many biomedical applications due to its specificity, strong binding, and nuclease resistance. This study is the initial data set that indicates PNA are recognized by translation enzymes.</p>

Name thesis:degree_name

Master of Science (MS)

Level thesis:degree_level

Masters Thesis

Discipline thesis:degree_discipline

Chemistry and Biochemistry

Year dc:date.available

2015

Author dc:creator

• Serrano, Crystal Cox

Contributors dc:contributor

• Anthony J. Bell Jr.
• Philip D. Bates
• Robert C. Bateman

• PNA
• aaRSs
• protein translation
• synthetic nucleic acids
• Biochemistry

Repository record dc:identifier

https://aquila.usm.edu/masters_theses/137

OAI identifier oai:identifier

oai:aquila.usm.edu:masters_theses-1143