Neuroimaging metrics of drug- and food-cue reactivity as a function of psychopathic traits, substance use, and substance dependence

We conducted two fMRI studies assessing the relationship between psychopathy and drug- and food-related neural reactivity. In the first study, we assessed the relationship between psychopathic traits and neural reactivity among 47 cocaine-dependent and 58 non-dependent participants. The cocaine-dependent group exhibited a neural processing bias towards drugrelated stimuli within a corticolimbic circuit involved in decision-making, salience attribution, and motivation. Psychopathic traits both sensitized this neural processing bias and modulated the effect of substance use severity. In the second study, we separated dependent participants into psychologically- (n =25) or physiologically-dependent (n = 20) participants and observed a neural processing bias towards drug-related stimuli among physiologically-dependent participants alone. Interestingly, both psychopathic traits and substance use severity exhibited positive correlations to drug > food reactivity within psychologically-dependent participants. These results further our understanding of the comorbidity between psychopathy and addiction and help conceptualize a new comprehensive model for the development of addiction.

Name thesis:degree_name

Master of Science (MSc)

Discipline thesis:degree_discipline

Forensic Psychology

Grantor

University of Ontario Institute of Technology

Year dc:date.issued

2018

Author dc:creator

• Denomme, William James

Advisor dc:contributor.advisor

• Shane, Matthew S.

• Addiction
• Psychopathy
• fMRI
• Neural processing
• Corticolimbic

Language dc:language.iso

en

Handle dc:identifier.uri

https://hdl.handle.net/10155/948

OAI identifier oai:identifier

oai:ontariotechu.scholaris.ca:10155/948