{"id":{"repo_id":"uoit","oai_identifier":"oai:ontariotechu.scholaris.ca:10155/948"},"canonical_url":"https://search.dev.ndltd.org/etd/uoit/oai:ontariotechu.scholaris.ca:10155/948","repository":{"repo_id":"uoit","name":"Ontario Institute of Technology","base_url":"https://ontariotechu.scholaris.ca/server/oai/request"},"display":{"title":"Neuroimaging metrics of drug- and food-cue reactivity as a function of psychopathic traits, substance use, and substance dependence","abstract":"We conducted two fMRI studies assessing the relationship between psychopathy and drug- and food-related neural reactivity. In the first study, we assessed the relationship between psychopathic traits and neural reactivity among 47 cocaine-dependent and 58 non-dependent participants. The cocaine-dependent group exhibited a neural processing bias towards drugrelated stimuli within a corticolimbic circuit involved in decision-making, salience attribution, and motivation. Psychopathic traits both sensitized this neural processing bias and modulated the effect of substance use severity. In the second study, we separated dependent participants into psychologically- (n =25) or physiologically-dependent (n = 20) participants and observed a neural processing bias towards drug-related stimuli among physiologically-dependent participants alone. Interestingly, both psychopathic traits and substance use severity exhibited positive correlations to drug > food reactivity within psychologically-dependent participants. These results further our understanding of the comorbidity between psychopathy and addiction and help conceptualize a new comprehensive model for the development of addiction.","abstract_html":"We conducted two fMRI studies assessing the relationship between psychopathy and drug- and food-related neural reactivity. In the first study, we assessed the relationship between psychopathic traits and neural reactivity among 47 cocaine-dependent and 58 non-dependent participants. The cocaine-dependent group exhibited a neural processing bias towards drugrelated stimuli within a corticolimbic circuit involved in decision-making, salience attribution, and motivation. Psychopathic traits both sensitized this neural processing bias and modulated the effect of substance use severity. In the second study, we separated dependent participants into psychologically- (n =25) or physiologically-dependent (n = 20) participants and observed a neural processing bias towards drug-related stimuli among physiologically-dependent participants alone. Interestingly, both psychopathic traits and substance use severity exhibited positive correlations to drug > food reactivity within psychologically-dependent participants. These results further our understanding of the comorbidity between psychopathy and addiction and help conceptualize a new comprehensive model for the development of addiction.","abstract_has_math":false,"creators":["Denomme, William James"],"institution":"University of Ontario Institute of Technology","degree_name":"Master of Science (MSc)","degree_level":null,"degree_discipline":"Forensic Psychology","degree_department":null,"school":null,"contributors":[],"advisors":["Shane, Matthew S."],"committee_chairs":[],"committee_members":[],"year":2018,"date_issued":"2018-08-01","date_published":"2018-08-01","updated_at":"2026-07-24T05:35:34Z","subjects":["Addiction","Psychopathy","fMRI","Neural processing","Corticolimbic"],"languages":["en"],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"https://hdl.handle.net/10155/948","outbound_label":"Handle","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor.advisor","label":"Advisor","values":["Shane, Matthew S."]},{"key":"dc:creator","label":"Author","values":["Denomme, William James"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2018-08-30T18:58:59Z","2022-03-29T17:43:19Z"]},{"key":"dc:date.available","label":"Dc Date Available","values":["2018-08-30T18:58:59Z","2022-03-29T17:43:19Z"]},{"key":"dc:date.issued","label":"Date","values":["2018-08-01"]},{"key":"dc:type","label":"Dc Type","values":["Thesis"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Forensic Psychology"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Master of Science (MSc)"]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["University of Ontario Institute of Technology"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Addiction","Psychopathy","fMRI","Neural processing","Corticolimbic"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language.iso","label":"Language (ISO)","values":["en"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.uri","label":"Identifier URI","values":["https://hdl.handle.net/10155/948"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["We conducted two fMRI studies assessing the relationship between psychopathy and drug- and food-related neural reactivity. In the first study, we assessed the relationship between psychopathic traits and neural reactivity among 47 cocaine-dependent and 58 non-dependent participants. The cocaine-dependent group exhibited a neural processing bias towards drugrelated stimuli within a corticolimbic circuit involved in decision-making, salience attribution, and motivation. Psychopathic traits both sensitized this neural processing bias and modulated the effect of substance use severity. In the second study, we separated dependent participants into psychologically- (n =25) or physiologically-dependent (n = 20) participants and observed a neural processing bias towards drug-related stimuli among physiologically-dependent participants alone. Interestingly, both psychopathic traits and substance use severity exhibited positive correlations to drug > food reactivity within psychologically-dependent participants. These results further our understanding of the comorbidity between psychopathy and addiction and help conceptualize a new comprehensive model for the development of addiction."]},{"key":"dc:title","label":"Title","values":["Neuroimaging metrics of drug- and food-cue reactivity as a function of psychopathic traits, substance use, and substance dependence"]}]}],"canonical_facts":{"dc:contributor.advisor":["Shane, Matthew S."],"dc:creator":["Denomme, William James"],"dc:date.accessioned":["2018-08-30T18:58:59Z","2022-03-29T17:43:19Z"],"dc:date.available":["2018-08-30T18:58:59Z","2022-03-29T17:43:19Z"],"dc:date.issued":["2018-08-01"],"dc:description.abstract":["We conducted two fMRI studies assessing the relationship between psychopathy and drug- and food-related neural reactivity. In the first study, we assessed the relationship between psychopathic traits and neural reactivity among 47 cocaine-dependent and 58 non-dependent participants. The cocaine-dependent group exhibited a neural processing bias towards drugrelated stimuli within a corticolimbic circuit involved in decision-making, salience attribution, and motivation. Psychopathic traits both sensitized this neural processing bias and modulated the effect of substance use severity. In the second study, we separated dependent participants into psychologically- (n =25) or physiologically-dependent (n = 20) participants and observed a neural processing bias towards drug-related stimuli among physiologically-dependent participants alone. Interestingly, both psychopathic traits and substance use severity exhibited positive correlations to drug > food reactivity within psychologically-dependent participants. These results further our understanding of the comorbidity between psychopathy and addiction and help conceptualize a new comprehensive model for the development of addiction."],"dc:identifier.uri":["https://hdl.handle.net/10155/948"],"dc:language.iso":["en"],"dc:subject":["Addiction","Psychopathy","fMRI","Neural processing","Corticolimbic"],"dc:title":["Neuroimaging metrics of drug- and food-cue reactivity as a function of psychopathic traits, substance use, and substance dependence"],"dc:type":["Thesis"],"thesis:degree_discipline":["Forensic Psychology"],"thesis:degree_name":["Master of Science (MSc)"],"thesis:institution_name":["University of Ontario Institute of Technology"]},"updated_at":"2026-07-24T05:35:34Z"}