The role of prostaglandins, nitric oxide and oxygen in the ductus arteriosi of the pre-term chicken embryo (Gallus domesticus).

The chicken ductus arteriosi (DA) are two embryonic blood vessels that shunt blood away from the non-ventilated lungs and towards the body and chorioallantoic membrane. I show that prostaglandins have a diminished role in maintaining chicken DA patency and nitric oxide inhibits oxygen induced contraction of the day 19 proximal DA in a time dependent manner. The pathways governing oxygen induced contraction in the chicken DA are similar to those found in mammals and include contributions from ROS, Kv channels, L-type Ca2+ channels, and the Rho kinase pathway. Longer exposure to high oxygen generates increased oxygen induced constriction of the day 19 DA that may be mediated through the Rho kinase pathway.

Grantor dc:publisher

University of North Texas

Year dc:date

2007

Author dc:creator

• Greyner, Henry José

Contributors dc:contributor

• Dzialowski, Edward M. (Edward Michael)
• Burggren, Warren W.
• Burleson, Mark

• prostaglandins
• chicken embryos
• smooth muscle contraction
• oxygen
• cardiovascular physiology
• Ductus arteriosus.
• Chickens -- Embryos -- Physiology.
• Prostaglandins.
• Nitric oxide.
• Oxygen.

Statement dc:rights

• Public
• Copyright
• Greyner, Henry José
• Copyright is held by the author, unless otherwise noted. All rights reserved.

Language dc:language

English

Identifier

oclc: 228008439
https://digital.library.unt.edu/ark:/67531/metadc5173/
ark: ark:/67531/metadc5173

OAI identifier oai:identifier

info:ark/67531/metadc5173