The Effects of Selective Serotonin Reuptake Inhibitors (Ssri) on Auditory Measures in Clinically Depressed Subjects.

The purpose of this study was to investigate the relationship between selective serotonin reuptake inhibitor (SSRI) medication on auditory skills in clinically depressed subjects. Experimental subjects prescribed an SSRI were tested in a medicated and an unmedicated condition, and the test results were compared. Furthermore, the experimental group was compared with a control group consisting of normal subjects. Test measures included pure tone audiometry, tympanometry, acoustic reflex thresholds, and auditory electrophysiologic measures such as auditory brainstem and auditory late responses. An assessment scale for depression (Beck Depression Inventory-II) was also used. Results indicated statistically significant differences for the BDI-II between the control and experimental groups for both conditions. Electrophysiologic measures indicated a significantly shorter latency for auditory late potential P1 at 55 dBnSL, and a significantly larger amplitude at 45 dBnSL for the N1/P2 component for the unmedicated group. Although the other measures showed trends, they did not reach significance.

Grantor dc:publisher

University of North Texas

Year dc:date

2002

Author dc:creator

• Goodale, Elizabeth S.

Contributors dc:contributor

• Gopal, Kamakshi V.
• Lu, Fang-Ling
• Ries, Dennis

• Auditory perception.
• Serotonin uptake inhibitors.
• Depressed persons.
• serotonin
• auditory processing
• N1/P2
• SSRI
• depression

Statement dc:rights

• Public
• Copyright
• Goodale, Elizabeth S.
• Copyright is held by the author, unless otherwise noted. All rights reserved.

Language dc:language

English

Identifier

oclc: 54843805
https://digital.library.unt.edu/ark:/67531/metadc3146/
ark: ark:/67531/metadc3146

OAI identifier oai:identifier

info:ark/67531/metadc3146