{"id":{"repo_id":"unt","oai_identifier":"info:ark/67531/metadc3146"},"canonical_url":"https://search.dev.ndltd.org/etd/unt/info:ark/67531/metadc3146","repository":{"repo_id":"unt","name":"University of North Texas","base_url":"https://digital.library.unt.edu/oai/"},"display":{"title":"The Effects of Selective Serotonin Reuptake Inhibitors (Ssri) on Auditory Measures in Clinically Depressed Subjects.","abstract":"The purpose of this study was to investigate the relationship between selective serotonin reuptake inhibitor (SSRI) medication on auditory skills in clinically depressed subjects. Experimental subjects prescribed an SSRI were tested in a medicated and an unmedicated condition, and the test results were compared. Furthermore, the experimental group was compared with a control group consisting of normal subjects. Test measures included pure tone audiometry, tympanometry, acoustic reflex thresholds, and auditory electrophysiologic measures such as auditory brainstem and auditory late responses. An assessment scale for depression (Beck Depression Inventory-II) was also used. Results indicated statistically significant differences for the BDI-II between the control and experimental groups for both conditions. Electrophysiologic measures indicated a significantly shorter latency for auditory late potential P1 at 55 dBnSL, and a significantly larger amplitude at 45 dBnSL for the N1/P2 component for the unmedicated group. Although the other measures showed trends, they did not reach significance.","abstract_html":"The purpose of this study was to investigate the relationship between selective serotonin reuptake inhibitor (SSRI) medication on auditory skills in clinically depressed subjects. Experimental subjects prescribed an SSRI were tested in a medicated and an unmedicated condition, and the test results were compared. Furthermore, the experimental group was compared with a control group consisting of normal subjects. Test measures included pure tone audiometry, tympanometry, acoustic reflex thresholds, and auditory electrophysiologic measures such as auditory brainstem and auditory late responses. An assessment scale for depression (Beck Depression Inventory-II) was also used. Results indicated statistically significant differences for the BDI-II between the control and experimental groups for both conditions. Electrophysiologic measures indicated a significantly shorter latency for auditory late potential P1 at 55 dBnSL, and a significantly larger amplitude at 45 dBnSL for the N1/P2 component for the unmedicated group. Although the other measures showed trends, they did not reach significance.","abstract_has_math":false,"creators":["Goodale, Elizabeth S."],"institution":"University of North Texas","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":["Gopal, Kamakshi V.","Lu, Fang-Ling","Ries, Dennis"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2002,"date_issued":"2002-05","date_published":"2002-05","updated_at":"2026-07-24T05:34:52Z","subjects":["Auditory perception.","Serotonin uptake inhibitors.","Depressed persons.","serotonin","auditory processing","N1/P2","SSRI","depression"],"languages":["English"],"rights":["Public","Copyright","Goodale, Elizabeth S.","Copyright is held by the author, unless otherwise noted. All rights reserved."],"rights_urls":[],"identifier_entries":[{"key":"dc:identifier","label":"Identifier","values":["oclc: 54843805","https://digital.library.unt.edu/ark:/67531/metadc3146/","ark: ark:/67531/metadc3146"],"render_values":[{"text":"oclc: 54843805","href":null,"code":true},{"text":"https://digital.library.unt.edu/ark:/67531/metadc3146/","href":"https://digital.library.unt.edu/ark:/67531/metadc3146/","code":true},{"text":"ark: ark:/67531/metadc3146","href":null,"code":true}]}]},"links":{"outbound_url":"https://doi.org/10.12794/metadc3146","outbound_label":"DOI","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Gopal, Kamakshi V.","Lu, Fang-Ling","Ries, Dennis"]},{"key":"dc:creator","label":"Author","values":["Goodale, Elizabeth S."]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2002-05"]},{"key":"dc:publisher","label":"Institution","values":["University of North Texas"]},{"key":"dc:type","label":"Dc Type","values":["Thesis or Dissertation"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Auditory perception.","Serotonin uptake inhibitors.","Depressed persons.","serotonin","auditory processing","N1/P2","SSRI","depression"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["English"]},{"key":"dc:rights","label":"Dc Rights","values":["Public","Copyright","Goodale, Elizabeth S.","Copyright is held by the author, unless otherwise noted. 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An assessment scale for depression (Beck Depression Inventory-II) was also used. Results indicated statistically significant differences for the BDI-II between the control and experimental groups for both conditions. Electrophysiologic measures indicated a significantly shorter latency for auditory late potential P1 at 55 dBnSL, and a significantly larger amplitude at 45 dBnSL for the N1/P2 component for the unmedicated group. Although the other measures showed trends, they did not reach significance."]},{"key":"dc:format","label":"Dc Format","values":["Text"]},{"key":"dc:title","label":"Title","values":["The Effects of Selective Serotonin Reuptake Inhibitors (Ssri) on Auditory Measures in Clinically Depressed Subjects."]}]}],"canonical_facts":{"dc:contributor":["Gopal, Kamakshi V.","Lu, Fang-Ling","Ries, Dennis"],"dc:creator":["Goodale, Elizabeth S."],"dc:date":["2002-05"],"dc:description":["The purpose of this study was to investigate the relationship between selective serotonin reuptake inhibitor (SSRI) medication on auditory skills in clinically depressed subjects. Experimental subjects prescribed an SSRI were tested in a medicated and an unmedicated condition, and the test results were compared. Furthermore, the experimental group was compared with a control group consisting of normal subjects. Test measures included pure tone audiometry, tympanometry, acoustic reflex thresholds, and auditory electrophysiologic measures such as auditory brainstem and auditory late responses. An assessment scale for depression (Beck Depression Inventory-II) was also used. Results indicated statistically significant differences for the BDI-II between the control and experimental groups for both conditions. Electrophysiologic measures indicated a significantly shorter latency for auditory late potential P1 at 55 dBnSL, and a significantly larger amplitude at 45 dBnSL for the N1/P2 component for the unmedicated group. Although the other measures showed trends, they did not reach significance."],"dc:format":["Text"],"dc:identifier":["oclc: 54843805","doi: 10.12794/metadc3146","https://digital.library.unt.edu/ark:/67531/metadc3146/","ark: ark:/67531/metadc3146"],"dc:language":["English"],"dc:publisher":["University of North Texas"],"dc:rights":["Public","Copyright","Goodale, Elizabeth S.","Copyright is held by the author, unless otherwise noted. All rights reserved."],"dc:subject":["Auditory perception.","Serotonin uptake inhibitors.","Depressed persons.","serotonin","auditory processing","N1/P2","SSRI","depression"],"dc:title":["The Effects of Selective Serotonin Reuptake Inhibitors (Ssri) on Auditory Measures in Clinically Depressed Subjects."],"dc:type":["Thesis or Dissertation"]},"updated_at":"2026-07-24T05:34:52Z"}