Immunohistochemical characterization of neuronal cilia in the rat central nervous system.

An anti-G"11 antibody was used to label neuronal cilia throughout the rat central nervous system. Immunoreactive cilia were observed in every examined region of the rat CNS, but not in monkey or mouse tissue. Antibodies to G"q and G"q/11 failed to label cilia. Immunoreactive cilia were observed as early as postnatal day 0 in spinal tissue, and postnatal day 3 in hypothalamic tissue. There was a statistically significant negative correlation between a region's mean cilium length and that region's distance to the nearest ventricle; regions nearest ventricles were those with the longest cilia. This correlation suggests neuronal cilia may function as chemosensors, detecting substances as they move out from the cerebrospinal fluid and into the extracellular space of the brain.

Grantor dc:publisher

University of North Texas

Year dc:date

2002

Author dc:creator

• Hughes, Rhome

Contributors dc:contributor

• Schwark, Harris
• Fuchs, Jannon L.
• Gross, Guenter W.

• Rats -- Nervous system.
• Cilia and ciliary motion.
• Immunohistochemistry.
• anti-G"11 antibody
• neuronal cilia
• chemosensors
• G protein
• ventricle distance

Statement dc:rights

• Public
• Copyright
• Hughes, Rhome
• Copyright is held by the author, unless otherwise noted. All rights reserved.

Language dc:language

English

Identifier

oclc: 54851834
https://digital.library.unt.edu/ark:/67531/metadc3136/
ark: ark:/67531/metadc3136

OAI identifier oai:identifier

info:ark/67531/metadc3136