Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 27 for “"chemosensors"”.
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Fluorescent chemosensors for exploring zinc metalloneurochemistry and detecting mercury in aqueous solution
Chapter 1. An Introduction to Zinc Metalloneurochemistry and Zinc Detection in Biology. This chapter presents an overview of zinc neurophysiology and pathology, which provides motivation for the design of new tools and tactics for zinc detection in vivo. A historical account of biological zinc …
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Manipulating Conjugation in electronic polymers and graphitic materials: chemosensors, precursor routes, and self-assembly
In Chapter 1, we synthesize dithienobenzotropone-based conjugated alternating copolymers by direct arylation polycondensation. Post-polymerization hydride reduction furnishes cross-conjugated copolymeric hydrogels that undergo phosphorylation and subsequent ionization upon exposure to chemical …
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Dendrimer Modified Silica Nanoparticles as Fluorescent Chemosensors for the Detection of Copper and Cyanide Ions
… series of silica nanoparticle-based fluorescent chemosensors were synthesized for the sensitive and selective detection of Cu<sup>2+ </sup>ions in aqueous solution and subsequent CN<sup>-</sup> ion detection. Silica nanoparticles (SNP) were modified with branching polyamidoamine (PAMAM) …
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Development of chemosensors for endocrine disrupting chemicals (EDCs): synthesis and evaluation of solid-phase bound receptors
Worldwide concern has been growing on the increasing distribution of endocrine disrupting chemicals (EDCs) during the last decade. The overall anxiety is caused by their effect on the endocrine system of wildlife and humans. While the influence on the reproductive systems of several animals has …
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Structure Activity Study of a Family of Functional Pyrene-Isoxazole-Calix[4]arene Fluorescent Chemosensors for Metal Ion Detection
This thesis reports onthedesign, synthesisand structural characterisationof a novel family of pyrene-isoxazole-calix[4]arenes. Aninvestigation of their metal cation sensing abilitiesusing techniques including absorbance, fluorescence and 1H NMR spectroscopiesfollows.The novel work begins by …
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Zinc(II) Schiff Base Complexes and their Aggregation/Deaggregation Properties: Versatile and Multifunctional Materials as Chemosensors and Building Blocks for New Supramolecular Architectures
In questa tesi di dottorato si riporta la sintesi, caratterizzazione e studio delle proprietà di aggregazione/disaggregazione di una serie di complessi anfifilici derivati da basi di Schiff bis(salicilaldiminato) di Zinco(II), con diversi gruppi diamminici a ponte, e le loro applicazioni come …
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Chemosensing strategies : utilizing the novel sulfonamidohydroxyquinoline amino acid Sox
Modular peptide-based fluorescent chemosensors utilizing the chelation-sensitive fluorophore 8-hydroxy-5-(N,N-dimethylsulfonamido)-2-methylquinoline are powerful tools for sensing Zn²⁺ and for sensing protein kinase activity. This signaling component is prepared as the protected amino acid …
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Organic multilayer photoconductor utilizing a spacer layer
Chemosensors hold many vital applications in today's world, particularly as detectors for explosives. There is still vast room for improvement as other technologies-particularly those of explosives-continue to evolve and expand. Herein, we develop a novel device structure with the potential for …
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Immunohistochemical characterization of neuronal cilia in the rat central nervous system.
… suggests neuronal cilia may function as chemosensors, detecting substances as they move out from the cerebrospinal fluid and into the extracellular space of the brain.
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Glass Foundation Chemosensor Synthesis and Functionality Analysis
<p>Chemosensors are created through a series of reaction steps on controlled pore class (CPG) and terminate with a Cu<sup>2+</sup> metal binding site. Each monolayer of reactant insures that the metal binding site exposed to solution would serve as an indicator displacement assay (IDA) sensor. The …
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Study of poly(phenylene ethynylene)s, dendritic quenchers, and molecular beacons towards the application of a poly(phenylene ethynylene)-based biosensor
… incorporated into sensing platforms, both as chemosensors and as biosensors. This thesis describes the three components necessary for a MB-based PPE biosensor, as well as preliminary work towards assembly of the components. A sensor system composed of three parts is presented: (1) a PPE with …
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Design and Frabication of Optical Li+ Sensors for Application in Li-ion Batteries
… to form highly selective and sensitive optical chemosensors. Subsequently, the design, synthesis, and characterisation of two novel Li+-selective fluorescent chemosensors based on a naphthalene diimide core are described. Although both displayed poor solubility in salt-solvent systems reflective …
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Synthesis, design and characterization of a distributed feedback grating based non-linear optical chemosensor
Current optical chemosensors that operate by a 3R sensing approach - recognize, relay and report -- generate a measurable luminescent signal in the presence of targeted analyte. However, the advancement of chemical sensing into the micro- and nanoscale regimes necessitates the development of new …
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Development of selective peptide- and protein-based reporters of kinase activity utilizing chelation-enhanced fluorescence
… determinants, which are used to construct chemosensors for multiple Ser/Thr and Tyr kinases with greatly enhanced selectivity. Moreover, a high throughput mass spectrometry-based screening method that builds additional selectivity into RDF Sox-based probes for Ser/Thr kinases was also …
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Designing conjugated polymer-based functional materials via the incorporation of supramolecular complexities
… CPs very desirable for the design of sensitive chemosensors. The incorporation of rotaxane moieties to poly(p-phenyleneethynylene)s will be described in Chapter Two. By design, the rotaxane groups behave as molecular recognition elements for the detection of small molecules. In addition, these …
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Design and Characterization of New Luminescent Sensors and Labels
… this context, we kept developing new molecular chemosensors, by exploiting the supramolecular approach, for different classes of analytes. In particular we studied a family of luminescent tetrapodal-hosts based on aminopyridinium units with pyrenyl groups for the detection of anions. These …
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The Development of Assays for Detecting Proximal Phosphorylation and Covalent Modification of Proteins
… libraries were designed and synthesized. Chemosensors were used for proximal phosphate detection in numerous biologically-relevant applications with a variety of assay types including fluorimetry, microscopy, polyacrylamide gels and flow cytometry. The second objective in assay development …
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A Characterization of Caffeine Imprinted Polypyrrole Electrode
… in chromatographic separation, drug screening, chemosensors, catalysis, immunoassays etc) due to their specificity towards the target molecules and high stability against physicochemical perturbations. Conductive polymers, (CPs) such as polypyrrole, can be likened to semiconductors because of …
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Fluorescent Materials for Chemical Sensing
… explorations of the unique properties of the chemosensors utilizing this platform. It encompasses bichromophoric fluorescent energy transfer cassettes consisting of a mono-disperse conjugated oligomer and a red-shifted energy transfer acceptor that is specifically reactive on the presence of a …
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Heterocyclic Calix[4]arene Derivatives for Fluorescence Investigations
… (1:1) and binding constant for these chemosensors. The mode of binding was also examined by 1H NMR spectra titration studies, and through molecular modelling studies which provides a coordination geometrical explanation of the selectivity for Cu2+.
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