A preliminary study of the effects of selective-serotonin re-uptake inhibitors (SSRIs) on central auditory processing

his study compared auditory behavioral and physiological measures among three subject groups: 1) Normal control subjects, 2) subjects who were on a prescribed SSRI for depression, and 3) subjects who were prescribed an SSRI for depression, but were not medicated at the time of testing. Test measures included: Standard audiological tests (audiometry and tympanometry), electrophysiological procedures for analysis of auditory- evoked brainstem and late responses, and standardized behavioral speech tests (SCAN-A, SSI, and the low predictability sentence list of the R-SPIN). Analysis of results indicated a statistically significant increase of group mean amplitude of the ABR peak V, from 15dBnSL to 55dBnSL, in the non-medicated group compared to controls. Also, the non-medicated group scored significantly less favorably than controls on the most challenging listening condition (-20 MCR) of the SSI, in the left ear. Although other test measures indicated consistent differences between these two groups, they were not, however, significant.

Grantor dc:publisher

University of North Texas

Year dc:date

2001

Author dc:creator

• Bishop, Charles E.

Contributors dc:contributor

• Gopal, Kamakshi V.
• Lu, Fang-Ling
• Henoch, Miriam A.
• Cokely, Jeffrey A

• Auditory perception.
• Serotonin uptake inhibitors.
• serotonin
• behavioral tests
• depression
• auditory processing
• auditory-evoked potentials

Statement dc:rights

• Use restricted to UNT Community
• Copyright
• Bishop Charles E.
• Copyright is held by the author, unless otherwise noted. All rights reserved.

Language dc:language

English

Identifier

oclc: 51309596
https://digital.library.unt.edu/ark:/67531/metadc2853/
ark: ark:/67531/metadc2853

OAI identifier oai:identifier

info:ark/67531/metadc2853