The Effects of Electrochemical Therapy on Colon-25 Tumors in Balb-C Mice

The purpose of the research was to treat immunodeficient mice, implanted with colon-25 tumors, with continuous and interrupted electrochemical therapy (ECT). ECT involves the placement of two electrodes, an anode near the center of the tumor and a cathode into the tumor periphery. A constant voltage is applied across the electrodes for a given period of time. The data showed that the interrupted and continuous ECT resulted in a decrease in mean tumor growth as compared to that of the sham controls. The histology of both ECT groups showed an increase presence of large vacuoles, randomly distributed tumor cells as well as the presence of "crevicing" in the medullary tissue. The differential leukocyte counts showed a distinct neutrophilia and lymphopenia in all groups at day 20 post tumor implantation. The results from the experimental groups appeared to support the findings of previous investigators.

Grantor dc:publisher

University of North Texas

Year dc:date

2000

Author dc:creator

• Gillen, Aric

Contributors dc:contributor

• Lott, James R.
• Zimmerman, Earl G.
• O'Donovan, Gerard A.
• Fuchs, Jannon L.

• Teachers -- Rating of -- Texas.
• ECT
• immunodeficient mice
• histology
• colon-25 tumors

Statement dc:rights

• Public
• Copyright
• Gillen, Aric
• Copyright is held by the author, unless otherwise noted. All rights reserved.

Language dc:language

English

Identifier

oclc: 47670311
https://digital.library.unt.edu/ark:/67531/metadc2720/
ark: ark:/67531/metadc2720

OAI identifier oai:identifier

info:ark/67531/metadc2720