{"id":{"repo_id":"unt","oai_identifier":"info:ark/67531/metadc2720"},"canonical_url":"https://search.dev.ndltd.org/etd/unt/info:ark/67531/metadc2720","repository":{"repo_id":"unt","name":"University of North Texas","base_url":"https://digital.library.unt.edu/oai/"},"display":{"title":"The Effects of Electrochemical Therapy on Colon-25 Tumors in Balb-C Mice","abstract":"The purpose of the research was to treat immunodeficient mice, implanted with colon-25 tumors, with continuous and interrupted electrochemical therapy (ECT). ECT involves the placement of two electrodes, an anode near the center of the tumor and a cathode into the tumor periphery. A constant voltage is applied across the electrodes for a given period of time. The data showed that the interrupted and continuous ECT resulted in a decrease in mean tumor growth as compared to that of the sham controls. The histology of both ECT groups showed an increase presence of large vacuoles, randomly distributed tumor cells as well as the presence of \"crevicing\" in the medullary tissue. The differential leukocyte counts showed a distinct neutrophilia and lymphopenia in all groups at day 20 post tumor implantation. The results from the experimental groups appeared to support the findings of previous investigators.","abstract_html":"The purpose of the research was to treat immunodeficient mice, implanted with colon-25 tumors, with continuous and interrupted electrochemical therapy (ECT). ECT involves the placement of two electrodes, an anode near the center of the tumor and a cathode into the tumor periphery. A constant voltage is applied across the electrodes for a given period of time. The data showed that the interrupted and continuous ECT resulted in a decrease in mean tumor growth as compared to that of the sham controls. The histology of both ECT groups showed an increase presence of large vacuoles, randomly distributed tumor cells as well as the presence of "crevicing" in the medullary tissue. The differential leukocyte counts showed a distinct neutrophilia and lymphopenia in all groups at day 20 post tumor implantation. The results from the experimental groups appeared to support the findings of previous investigators.","abstract_has_math":false,"creators":["Gillen, Aric"],"institution":"University of North Texas","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":["Lott, James R.","Zimmerman, Earl G.","O'Donovan, Gerard A.","Fuchs, Jannon L."],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2000,"date_issued":"2000-12","date_published":"2000-12","updated_at":"2026-07-24T05:34:52Z","subjects":["Teachers -- Rating of -- Texas.","ECT","immunodeficient mice","histology","colon-25 tumors"],"languages":["English"],"rights":["Public","Copyright","Gillen, Aric","Copyright is held by the author, unless otherwise noted. All rights reserved."],"rights_urls":[],"identifier_entries":[{"key":"dc:identifier","label":"Identifier","values":["oclc: 47670311","https://digital.library.unt.edu/ark:/67531/metadc2720/","ark: ark:/67531/metadc2720"],"render_values":[{"text":"oclc: 47670311","href":null,"code":true},{"text":"https://digital.library.unt.edu/ark:/67531/metadc2720/","href":"https://digital.library.unt.edu/ark:/67531/metadc2720/","code":true},{"text":"ark: ark:/67531/metadc2720","href":null,"code":true}]}]},"links":{"outbound_url":"https://doi.org/10.12794/metadc2720","outbound_label":"DOI","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Lott, James R.","Zimmerman, Earl G.","O'Donovan, Gerard A.","Fuchs, Jannon L."]},{"key":"dc:creator","label":"Author","values":["Gillen, Aric"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2000-12"]},{"key":"dc:publisher","label":"Institution","values":["University of North Texas"]},{"key":"dc:type","label":"Dc Type","values":["Thesis or Dissertation"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Teachers -- Rating of -- Texas.","ECT","immunodeficient mice","histology","colon-25 tumors"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["English"]},{"key":"dc:rights","label":"Dc Rights","values":["Public","Copyright","Gillen, Aric","Copyright is held by the author, unless otherwise noted. 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The histology of both ECT groups showed an increase presence of large vacuoles, randomly distributed tumor cells as well as the presence of \"crevicing\" in the medullary tissue. The differential leukocyte counts showed a distinct neutrophilia and lymphopenia in all groups at day 20 post tumor implantation. The results from the experimental groups appeared to support the findings of previous investigators."]},{"key":"dc:format","label":"Dc Format","values":["Text"]},{"key":"dc:title","label":"Title","values":["The Effects of Electrochemical Therapy on Colon-25 Tumors in Balb-C Mice"]}]}],"canonical_facts":{"dc:contributor":["Lott, James R.","Zimmerman, Earl G.","O'Donovan, Gerard A.","Fuchs, Jannon L."],"dc:creator":["Gillen, Aric"],"dc:date":["2000-12"],"dc:description":["The purpose of the research was to treat immunodeficient mice, implanted with colon-25 tumors, with continuous and interrupted electrochemical therapy (ECT). ECT involves the placement of two electrodes, an anode near the center of the tumor and a cathode into the tumor periphery. A constant voltage is applied across the electrodes for a given period of time. The data showed that the interrupted and continuous ECT resulted in a decrease in mean tumor growth as compared to that of the sham controls. The histology of both ECT groups showed an increase presence of large vacuoles, randomly distributed tumor cells as well as the presence of \"crevicing\" in the medullary tissue. The differential leukocyte counts showed a distinct neutrophilia and lymphopenia in all groups at day 20 post tumor implantation. The results from the experimental groups appeared to support the findings of previous investigators."],"dc:format":["Text"],"dc:identifier":["oclc: 47670311","doi: 10.12794/metadc2720","https://digital.library.unt.edu/ark:/67531/metadc2720/","ark: ark:/67531/metadc2720"],"dc:language":["English"],"dc:publisher":["University of North Texas"],"dc:rights":["Public","Copyright","Gillen, Aric","Copyright is held by the author, unless otherwise noted. All rights reserved."],"dc:subject":["Teachers -- Rating of -- Texas.","ECT","immunodeficient mice","histology","colon-25 tumors"],"dc:title":["The Effects of Electrochemical Therapy on Colon-25 Tumors in Balb-C Mice"],"dc:type":["Thesis or Dissertation"]},"updated_at":"2026-07-24T05:34:52Z"}