Secreted Factors from CD36+ Fibroblasts Induce Tumor Suppression in Subtypes of Breast Cancer

Human breast cancers are not fully autonomous. They are dependent on nutrients and growth-promoting signals provided by stromal cells. In order to instruct the surrounding cells to provide essential growth factors, cancer cells co-opt normal signaling molecules and mechanisms. To inhibit or potentially reverse tumor growth, our goal is to emulate this signaling and reprogram the microenvironment. For example, in a healthy mammary gland, fibroblasts (FBs) overexpress CD36; the downregulation of CD36 is one of the hallmarks of cancer-associated FBs. Therefore, in this project, we hypothesized that signaling from CD36+ FBs could cause growth suppression in a subset of breast cancer cell lines. We then designed a series of experiments to validate this growth suppression and elucidate secreted factors by CD36+ FBs that induce growth suppression. These experiments suggested three protein ligands of SLIT3, FBLN1, and PENK induce growth suppression in a subset of breast cancer subtypes.

Level thesis:degree_level

Doctorate Degree

Year dc:date.issued

2021

Author dc:creator

• Jabbari, Kosar

Advisor dc:contributor.advisor

• Parvin, Bahram

Committee members dc:contributor.committeemember

• Shen, Yantao
• Zhu, Xiaoshan
• Zaklit, Josette
• Alvarez-Ponce, David

Handle dc:identifier.uri

http://hdl.handle.net/11714/8051

OAI identifier oai:identifier

oai:scholarwolf.unr.edu:11714/8051