{"id":{"repo_id":"unr","oai_identifier":"oai:scholarwolf.unr.edu:11714/8051"},"canonical_url":"https://search.dev.ndltd.org/etd/unr/oai:scholarwolf.unr.edu:11714/8051","repository":{"repo_id":"unr","name":"University of Nevada - Reno","base_url":"https://scholarwolf.unr.edu/server/oai/request"},"display":{"title":"Secreted Factors from CD36+ Fibroblasts Induce Tumor Suppression in Subtypes of Breast Cancer","abstract":"Human breast cancers are not fully autonomous. They are dependent on nutrients and growth-promoting signals provided by stromal cells. In order to instruct the surrounding cells to provide essential growth factors, cancer cells co-opt normal signaling molecules and mechanisms. To inhibit or potentially reverse tumor growth, our goal is to emulate this signaling and reprogram the microenvironment. For example, in a healthy mammary gland, fibroblasts (FBs) overexpress CD36; the downregulation of CD36 is one of the hallmarks of cancer-associated FBs. Therefore, in this project, we hypothesized that signaling from CD36+ FBs could cause growth suppression in a subset of breast cancer cell lines. We then designed a series of experiments to validate this growth suppression and elucidate secreted factors by CD36+ FBs that induce growth suppression. These experiments suggested three protein ligands of SLIT3, FBLN1, and PENK induce growth suppression in a subset of breast cancer subtypes.","abstract_html":"Human breast cancers are not fully autonomous. They are dependent on nutrients and growth-promoting signals provided by stromal cells. In order to instruct the surrounding cells to provide essential growth factors, cancer cells co-opt normal signaling molecules and mechanisms. To inhibit or potentially reverse tumor growth, our goal is to emulate this signaling and reprogram the microenvironment. For example, in a healthy mammary gland, fibroblasts (FBs) overexpress CD36; the downregulation of CD36 is one of the hallmarks of cancer-associated FBs. Therefore, in this project, we hypothesized that signaling from CD36+ FBs could cause growth suppression in a subset of breast cancer cell lines. We then designed a series of experiments to validate this growth suppression and elucidate secreted factors by CD36+ FBs that induce growth suppression. These experiments suggested three protein ligands of SLIT3, FBLN1, and PENK induce growth suppression in a subset of breast cancer subtypes.","abstract_has_math":false,"creators":["Jabbari, Kosar"],"institution":null,"degree_name":null,"degree_level":"Doctorate Degree","degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":["Parvin, Bahram"],"committee_chairs":[],"committee_members":["Shen, Yantao","Zhu, Xiaoshan","Zaklit, Josette","Alvarez-Ponce, David"],"year":2021,"date_issued":"2021","date_published":"2021","updated_at":"2026-07-27T21:48:09Z","subjects":[],"languages":[],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/11714/8051","outbound_label":"Handle","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor.advisor","label":"Advisor","values":["Parvin, Bahram"]},{"key":"dc:contributor.committeemember","label":"Committee Member","values":["Shen, Yantao","Zhu, Xiaoshan","Zaklit, Josette","Alvarez-Ponce, David"]},{"key":"dc:creator","label":"Author","values":["Jabbari, Kosar"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2022-01-28T02:08:08Z"]},{"key":"dc:date.issued","label":"Date","values":["2021"]},{"key":"dc:type","label":"Dc Type","values":["Dissertation"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Doctorate Degree"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.uri","label":"Identifier URI","values":["http://hdl.handle.net/11714/8051"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["Human breast cancers are not fully autonomous. They are dependent on nutrients and growth-promoting signals provided by stromal cells. In order to instruct the surrounding cells to provide essential growth factors, cancer cells co-opt normal signaling molecules and mechanisms. To inhibit or potentially reverse tumor growth, our goal is to emulate this signaling and reprogram the microenvironment. For example, in a healthy mammary gland, fibroblasts (FBs) overexpress CD36; the downregulation of CD36 is one of the hallmarks of cancer-associated FBs. Therefore, in this project, we hypothesized that signaling from CD36+ FBs could cause growth suppression in a subset of breast cancer cell lines. We then designed a series of experiments to validate this growth suppression and elucidate secreted factors by CD36+ FBs that induce growth suppression. These experiments suggested three protein ligands of SLIT3, FBLN1, and PENK induce growth suppression in a subset of breast cancer subtypes."]},{"key":"dc:format","label":"Dc Format","values":["PDF"]},{"key":"dc:title","label":"Title","values":["Secreted Factors from CD36+ Fibroblasts Induce Tumor Suppression in Subtypes of Breast Cancer"]}]}],"canonical_facts":{"dc:contributor.advisor":["Parvin, Bahram"],"dc:contributor.committeemember":["Shen, Yantao","Zhu, Xiaoshan","Zaklit, Josette","Alvarez-Ponce, David"],"dc:creator":["Jabbari, Kosar"],"dc:date.accessioned":["2022-01-28T02:08:08Z"],"dc:date.issued":["2021"],"dc:description.abstract":["Human breast cancers are not fully autonomous. They are dependent on nutrients and growth-promoting signals provided by stromal cells. In order to instruct the surrounding cells to provide essential growth factors, cancer cells co-opt normal signaling molecules and mechanisms. To inhibit or potentially reverse tumor growth, our goal is to emulate this signaling and reprogram the microenvironment. For example, in a healthy mammary gland, fibroblasts (FBs) overexpress CD36; the downregulation of CD36 is one of the hallmarks of cancer-associated FBs. Therefore, in this project, we hypothesized that signaling from CD36+ FBs could cause growth suppression in a subset of breast cancer cell lines. We then designed a series of experiments to validate this growth suppression and elucidate secreted factors by CD36+ FBs that induce growth suppression. These experiments suggested three protein ligands of SLIT3, FBLN1, and PENK induce growth suppression in a subset of breast cancer subtypes."],"dc:format":["PDF"],"dc:identifier.uri":["http://hdl.handle.net/11714/8051"],"dc:title":["Secreted Factors from CD36+ Fibroblasts Induce Tumor Suppression in Subtypes of Breast Cancer"],"dc:type":["Dissertation"],"thesis:degree_level":["Doctorate Degree"]},"updated_at":"2026-07-27T21:48:09Z"}