Synthesis and Development of Potential CB1 Receptor Neutral Antagonists

<p>Cannabis and its derivatives have been used for both medicinal and recreational purposes. The study of this plant led to the discovery of over 60 cannabinoids, found exclusively in cannabis, that contribute to the behavioral effects of cannabis use, the most common is delta-9-tetrahydrocannabinol. Cannabinoid receptors function to increase activity in the mesolimbic dopamine reward system. Dopamine is a neurotransmitter that plays a major role in addition and its regulation plays a crucial role in mental and physical well-being. There is evidence that CB₁ receptors are important to the reinforcing effects and the development of physical dependence on opiate drugs. Studies have shown that increased levels of dopamine are consistent with addiction while reduced levels lead to a decline in recreational use.</p> <p>The goal of this research is to design, synthesize and develop potential CB₁ receptors that exhibit a neutral cannabinoid antagonist pharmacological profile.</p>

Name thesis:degree_name

M.S.

Level thesis:degree_level

Thesis

Discipline thesis:degree_discipline

Chemistry

Year

2012

Author dc:creator

• Slaughter, Kimari

Contributors dc:contributor

• Trudell, Mark L.
• Jursic, Branko
• Wang, Guijun

• Cannabinoids, Cannabinoid receptors, Dopamine, Benzhydryl Azetidines, Diols, Oximes, Amines
• Medicinal-Pharmaceutical Chemistry
• Organic Chemistry

Repository record dc:identifier

https://scholarworks.uno.edu/td/1483

OAI identifier oai:identifier

oai:scholarworks.uno.edu:td-2506