Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"physical dependence"”.
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Lower Extremities Muscle Strength Associated With Early Signs of Mobility Dependence among Older Adults Age 65 Years and Older
… Clinical mobility disability is associated with physical dependence, poor quality of life, and mortality. Treatment of age-related clinical mobility disability should focus on the prevention of the condition rather than its consequences. Identifying opportunities for early screening and …
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Synthesis and Development of Potential CB1 Receptor Neutral Antagonists
… regulation plays a crucial role in mental and physical well-being. There is evidence that CB<sub>1</sub> receptors are important to the reinforcing effects and the development of physical dependence on opiate drugs. Studies have shown that increased levels of dopamine are consistent with …
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Development of Non-covalent Chemical Probes for μ, δ and κ Opioid Receptors
… analgesics, continued use and abuse can lead to physical dependence and withdrawal symptoms. Their side effects, such as constipation, respiratory depression, and the development of tolerance, addiction liability and abuse, highlight the need for safer opioid prescribing practices. The …
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Synthesis and Evaluation of Dual-Acting Ligands for Mu Opioid And Neuropeptide FF Receptors
… side effects such as constipation, addiction, physical dependence, respiratory depression, and physiological tolerance that leads to hyperalgesia. Receptor desensitization due to excessive receptor activation by an agonist is but one source of physiological tolerance; it can also develop …
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The Effect of Variability in Substance Abuse and Dependence Terminology on Physicians' Prescribing Decisions
… craving, drug-seeking behavior, psychological dependence, and withdrawal with addiction than with drug dependence, while more physicians felt that physical dependence and tolerance were necessary for drug dependence. The most frequently used sources for drug information were the Physicians' …
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Effect of vasodilation on the response of muscle protein synthesis to insulin in aging
… is an important contributor to disability and physical dependence in older people. Studies have recently found that aging is associated with a relative resistance of muscle proteins to the anabolic action of insulin, even in subjects who do not have diabetes. This alteration impairs the …
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SMOKERS AND SMOKING: AN IN-DEPTH INTERVIEW STUDY OF INITIATION, TRANSITION, MAINTENANCE, AND CESSATION
… of smoking patterns. The model proposes that physical tolerance for cigarettes determines smoking rate and smoking rate, initiation environment, and dominant affective states determine eventual smoking patterns.</p><p>Among the findings were the following: Transition to regular smoking was …
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Synthesis of Analogues Based on the Opioid Alkaloid Mitragynine
… the administration of these opioid analgesics, physical dependence and addiction are the most undesirable ones. Currently, pharmacological approaches to treat opioid dependence include mainly methadone and LAAM (mu-agonists), buprenorphine (mu-partial agonist) and clonidine (alpha2-adrenergic …
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Dopamine Uptake Inhibition Potency Fluctuations of Cocaine at the Dopamine Transporter
… in the reward areas of the brain resulting in physical dependence on the drug. Amphetamines are psychotomimetics that act as substrates at the DAT and potentiate dopaminergic neurotransmission leading to addiction. It was previously reported that a conservative glutamate-for-aspartate …
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Landauer's theory of charge and spin transport in magnetic multilayers
… formalism before showing for the first time the physical dependence on multiple magnetic interfaces of the out-of-plane spin current in a nonmagnetic spacer and how the out-of-plane spin current in the spacer can be large even when the charge current and the in-plane spin current are both …
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A COMPARISION OF DELTA-9-TETRAHYDROCANNABINOL DEPENDENCE IN C57Bl/6j MICE AND FATTY ACID AMIDE HYDROLASE KNOCK OUT MICE
… that humans and laboratory animals can become physically dependent on marijuana or its primary psychoactive constituent, delta-9-tetrahydrocannabinol (THC), is gaining acceptance. However, there are no currently approved pharmacotherapies to treat cannabinoid withdrawal. The objective of this …