Heat shock proteins as indicators of environmental stress

In order to determine whether heat shock proteins (HSP) can be used as indicators of environmental stress in the mammalian organism Peromyscus leucopus, three doses of each of two chemical stresses, cadmium chloride and 2,4,5-trichlorophenoxyacetic acid (2,4,5-T), were given intraperitoneally for 14 days. Proteins extracted from liver samples were compared by one-dimensional gel electrophoresis to liver protein samples from heat shocked and control animals. HSPs of 105,78, and 43 kDa were cadmium inducible. Non-heat shocked cadmium inducible proteins of 118, 55, and 47 kDa were seen. 2,4,5-T induced an increase in a 91 kDa protein. Low level cadmium induction of HSPs suggests useful applications in toxicological and general environmental tests.

Name thesis:degree_name

Master of Science (MS)

Level thesis:degree_level

Thesis

Discipline thesis:degree_discipline

Biological Science

Grantor dc:publisher

University of Nevada, Las Vegas

Year

1997

Author dc:creator

• Castle, Arthur Louis

Contributors dc:contributor

• R. Keith Dupre
• Penny S. Amy

Statement dc:rights

• IN COPYRIGHT. For more information about this rights statement, please visit http://rightsstatements.org/vocab/InC/1.0/

Language dc:language

English

Identifier

https://oasis.library.unlv.edu/rtds/3

OAI identifier oai:identifier

oai:oasis.library.unlv.edu:rtds-1002