Clear, Aqueous Topical Nanomicelle Formulation For Diabetic Macula Edema

The objective of this study was to develop a clear aqueous mixed nanomicellar formulation (NMF) of hydrophobic drugs for diabetic macula edema. The hydrophobic drugs include triamcinolone acetonide (TA), fluocinolonce acetonide (FA) and triamcinolone (T1) were encapsulated with a combination of nonionic surfactant hydrogenated castor oil (HCO) and octoxynol-40 (Oc-40). A design of experiment (DOE) with JMP software was performed to optimize the formulation to delineate the effects of drug-polymer interactions. In this study, the amount of polymers HCO and OC-40 as independent variables. All formulations were prepared following solvent evaporation and film rehydration method, characterized with size, polydispersity, shape, morphology, clarity/ appearance and cytotoxicity on human corneal and retinal cell lines. A specific blend of HCO and Oc-40 at a particular wt% ratio which produced highest desirability generated by JMP software. The optimized formulations were characterized with all standard and safe and potentially suitable for ocular eye drop for future study.

Name thesis:degree_name

Ph.D.

Level thesis:degree_level

Doctoral

Discipline thesis:degree_discipline

Pharmaceutical Sciences (UMKC)

Grantor dc:publisher

University of Missouri -- Kansas City

Year dc:date.issued

2018

Author dc:creator

• Trinh, Hoang My

Advisor dc:contributor.advisor

• Mitra, Ashim K., 1954-

Language dc:language.iso

en_US

Handle dc:identifier.uri

https://hdl.handle.net/10355/66797

OAI identifier oai:identifier

oai:mospace.umsystem.edu:10355/66797