{"id":{"repo_id":"umkc","oai_identifier":"oai:mospace.umsystem.edu:10355/66797"},"canonical_url":"https://search.dev.ndltd.org/etd/umkc/oai:mospace.umsystem.edu:10355/66797","repository":{"repo_id":"umkc","name":"University of Missouri - Kansas City","base_url":"https://mospace.umsystem.edu/oai/request"},"display":{"title":"Clear, Aqueous Topical Nanomicelle Formulation For Diabetic Macula Edema","abstract":"The objective of this study was to develop a clear aqueous mixed nanomicellar formulation (NMF) of hydrophobic drugs for diabetic macula edema. The hydrophobic drugs include triamcinolone acetonide (TA), fluocinolonce acetonide (FA) and triamcinolone (T1) were encapsulated with a combination of nonionic surfactant hydrogenated castor oil (HCO) and octoxynol-40 (Oc-40). A design of experiment (DOE) with JMP software was performed to optimize the formulation to delineate the effects of drug-polymer interactions. In this study, the amount of polymers HCO and OC-40 as independent variables. All formulations were prepared following solvent evaporation and film rehydration method, characterized with size, polydispersity, shape, morphology, clarity/ appearance and cytotoxicity on human corneal and retinal cell lines. A specific blend of HCO and Oc-40 at a particular wt% ratio which produced highest desirability generated by JMP software. The optimized formulations were characterized with all standard and safe and potentially suitable for ocular eye drop for future study.","abstract_html":"The objective of this study was to develop a clear aqueous mixed nanomicellar formulation (NMF) of hydrophobic drugs for diabetic macula edema. The hydrophobic drugs include triamcinolone acetonide (TA), fluocinolonce acetonide (FA) and triamcinolone (T1) were encapsulated with a combination of nonionic surfactant hydrogenated castor oil (HCO) and octoxynol-40 (Oc-40). A design of experiment (DOE) with JMP software was performed to optimize the formulation to delineate the effects of drug-polymer interactions. In this study, the amount of polymers HCO and OC-40 as independent variables. All formulations were prepared following solvent evaporation and film rehydration method, characterized with size, polydispersity, shape, morphology, clarity/ appearance and cytotoxicity on human corneal and retinal cell lines. A specific blend of HCO and Oc-40 at a particular wt% ratio which produced highest desirability generated by JMP software. The optimized formulations were characterized with all standard and safe and potentially suitable for ocular eye drop for future study.","abstract_has_math":false,"creators":["Trinh, Hoang My"],"institution":"University of Missouri -- Kansas City","degree_name":"Ph.D.","degree_level":"Doctoral","degree_discipline":"Pharmaceutical Sciences (UMKC)","degree_department":null,"school":null,"contributors":[],"advisors":["Mitra, Ashim K., 1954-"],"committee_chairs":[],"committee_members":[],"year":2018,"date_issued":"2018","date_published":"2018","updated_at":"2026-07-24T05:16:44Z","subjects":[],"languages":["en_US"],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"https://hdl.handle.net/10355/66797","outbound_label":"Handle","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor.advisor","label":"Advisor","values":["Mitra, Ashim K., 1954-"]},{"key":"dc:creator","label":"Author","values":["Trinh, Hoang My"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2018-12-17T17:21:06Z"]},{"key":"dc:date.available","label":"Dc Date Available","values":["2018-12-17T17:21:06Z"]},{"key":"dc:date.issued","label":"Date","values":["2018"]},{"key":"dc:publisher","label":"Institution","values":["University of Missouri -- Kansas City"]},{"key":"dc:type","label":"Dc Type","values":["Thesis"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Pharmaceutical Sciences (UMKC)","Chemistry (UMKC)"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Doctoral"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Ph.D."]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["University of Missouri--Kansas City"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language.iso","label":"Language (ISO)","values":["en_US"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.uri","label":"Identifier URI","values":["https://hdl.handle.net/10355/66797"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Title from PDF of title page viewed December 21, 2018","Dissertation advisor: Ashim K. Mitra","Vita","Includes bibliographical references (pages 192-214)","Thesis (Ph.D.)--School of Pharmacy and Department of Chemistry. University of Missouri--Kansas City, 2018"]},{"key":"dc:description.abstract","label":"Abstract","values":["The objective of this study was to develop a clear aqueous mixed nanomicellar formulation (NMF) of hydrophobic drugs for diabetic macula edema. The hydrophobic drugs include triamcinolone acetonide (TA), fluocinolonce acetonide (FA) and triamcinolone (T1) were encapsulated with a combination of nonionic surfactant hydrogenated castor oil (HCO) and octoxynol-40 (Oc-40). A design of experiment (DOE) with JMP software was performed to optimize the formulation to delineate the effects of drug-polymer interactions. In this study, the amount of polymers HCO and OC-40 as independent variables. All formulations were prepared following solvent evaporation and film rehydration method, characterized with size, polydispersity, shape, morphology, clarity/ appearance and cytotoxicity on human corneal and retinal cell lines. A specific blend of HCO and Oc-40 at a particular wt% ratio which produced highest desirability generated by JMP software. The optimized formulations were characterized with all standard and safe and potentially suitable for ocular eye drop for future study."]},{"key":"dc:title","label":"Title","values":["Clear, Aqueous Topical Nanomicelle Formulation For Diabetic Macula Edema"]}]}],"canonical_facts":{"dc:contributor.advisor":["Mitra, Ashim K., 1954-"],"dc:creator":["Trinh, Hoang My"],"dc:date.accessioned":["2018-12-17T17:21:06Z"],"dc:date.available":["2018-12-17T17:21:06Z"],"dc:date.issued":["2018"],"dc:description":["Title from PDF of title page viewed December 21, 2018","Dissertation advisor: Ashim K. 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All formulations were prepared following solvent evaporation and film rehydration method, characterized with size, polydispersity, shape, morphology, clarity/ appearance and cytotoxicity on human corneal and retinal cell lines. A specific blend of HCO and Oc-40 at a particular wt% ratio which produced highest desirability generated by JMP software. The optimized formulations were characterized with all standard and safe and potentially suitable for ocular eye drop for future study."],"dc:identifier.uri":["https://hdl.handle.net/10355/66797"],"dc:language.iso":["en_US"],"dc:publisher":["University of Missouri -- Kansas City"],"dc:title":["Clear, Aqueous Topical Nanomicelle Formulation For Diabetic Macula Edema"],"dc:type":["Thesis"],"thesis:degree_discipline":["Pharmaceutical Sciences (UMKC)","Chemistry (UMKC)"],"thesis:degree_level":["Doctoral"],"thesis:degree_name":["Ph.D."],"thesis:institution_name":["University of Missouri--Kansas City"]},"updated_at":"2026-07-24T05:16:44Z"}