The early history and emergence of molecular functions and modular scale-free network behavior

The formation of protein structural domains requires that biochemical functions, defined by conserved amino acid sequence motifs, be embedded into a structural scaffold. Here we trace domain history onto a bipartite network of elementary functional loop (EFL) sequences and domain structures defined at the fold superfamily (FSF) level of Structural Classification of Proteins (SCOP). The resulting ‘elementary functionome’ network and its EFL and FSF graph projections unfold evolutionary ‘waterfalls’ describing emergence of primordial functions. Waterfalls reveal how ancient EFLs are shared by FSF structures in two initial waves of functional innovation that involve founder ‘p-loop’ and ‘winged helix’ domain structures. They also uncover a dynamics of modular motif embedding in domain structures that is ongoing, which transfers ‘preferential’ cooption properties of ancient EFLs to emerging FSFs. Remarkably, we find that the emergence of molecular functions induces hierarchical modularity and power law behavior in network evolution as the networks of motifs and structures expand metabolic pathways and translation.

Name thesis:degree_name

M.S.

Level thesis:degree_level

Thesis

Discipline thesis:degree_discipline

Bioinformatics

Grantor

University of Illinois at Urbana-Champaign

Year dc:date

2016

Author dc:creator

• Aziz, Muhammad Fayez

Contributors dc:contributor

• Caetano-Anollés, Gustavo
• Rodriguez-Zas, Sandra Luisa
• Bhalerao, Kaustubh
• Ma, Jian

• Protein domains
• Elementary loop sequences
• Bipartite network
• Network projections
• Evolutionary timeline
• Molecular functions
• Scale-free dynamics
• Modularity

Statement dc:rights

• Copyright 2015 Muhammad Fayez Aziz. Materials in this document (all chapters, including the abstract) are reprinted, with permission, from Aziz MF, Caetano-Anollés K and Caetano-Anollés G, 2015, “The early history and emergence of molecular functions and modular scale-free network behavior,” manuscript submitted

Language dc:language

en

Handle dc:identifier

http://hdl.handle.net/2142/89192

OAI identifier oai:identifier

oai:www.ideals.illinois.edu:2142/89192