Characterization of the Anti-Inflammatory Effects of the Molluscum Contagiosum Virus MC160 Protein

Using a series of MC160 deletion mutant proteins, we found that two distinct regions of the MC160 protein independently inhibit TNF-mediated NF-kappaB activation. Specifically, we observed that the second DED of MC160 interacts with procaspase-8 as a means to inhibit NF-kappaB activation, while the C-terminus of MC160 interacts with the chaperone Hsp90. Because both procaspase-8 and Hsp90 associate with the IKK complex, we believe that the MC160 protein binds these proteins as a means to destabilize the IKK complex, resulting in reduced IKK activation, and ultimately, inhibition of NF-kappaB activation.

Name thesis:degree_name

Ph.D.

Level thesis:degree_level

Dissertation

Grantor

University of Illinois at Urbana-Champaign

Year dc:date

2015

Author dc:creator

• Nichols, Daniel B.

Contributors dc:contributor

• Joanna Shisler

• Biology, Virology

Language dc:language

eng

Identifier

(MiAaPQ)AAI3347488

OAI identifier oai:identifier

oai:www.ideals.illinois.edu:2142/88341