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University of Illinois at Urbana-Champaign
Mass Spectrometric Interrogation of Thioester-Bound Intermediates on Nonribosomal Peptide and Polyketide Assembly Lines
Abstract
dc:descriptionInnovative developments in MS continue to increase the complexity of biological systems amenable for study and provide exciting research opportunities at interdisciplinary boundaries. The doctoral studies presented here have furthered the understanding of the biosynthesis of key natural products produced by NRPSs and PKSs. Valuable information has been attained by intersecting interests in pharmacognosy with enzymology and by pushing the limits of current analytical technologies. Further, this research has solidified an intellectual framework to enhance the bioengineering of novel catalysts for creation of new biologically relevant compounds.
Degree
thesis:*- Name thesis:degree_name
- Ph.D.
- Level thesis:degree_level
- Dissertation
- Grantor
- University of Illinois at Urbana-Champaign
- Year dc:date
- 2015
Author and committee
dc:creator, dc:contributor.*- Author dc:creator
-
- Hicks, Leslie Mae
- Contributors dc:contributor
-
- Kelleher, Neil L.
Subjects
dc:subject × 1Rights
- Language dc:language
- eng
Identifiers
dc:identifier.*- Identifier
- (MiAaPQ)AAI3202104
- OAI identifier oai:identifier
- oai:www.ideals.illinois.edu:2142/87886