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University of Illinois at Urbana-Champaign
Farnesyl Pyrophosphate/geranylgeranyl Pyrophosphate Synthase of Toxoplasma Gondii: Its Role in the Parasite Isoprenoid Pathway and as a Target for Bisphosphonates
Abstract
dc:descriptionIn summary, this work provides information to understand the isoprenoid pathway in T. gondii by isolation and characterization of an important enzyme in the pathway, TgFGGPS. Identification of TgFGGPS as the molecular target of bisphosphonates in this work provides a key tool for rational-based drug design. In addition, this work represents a new approach to chemotherapy of toxoplasmosis with a group of safe and easy to prepare compounds.
Degree
thesis:*- Name thesis:degree_name
- Ph.D.
- Level thesis:degree_level
- Dissertation
- Discipline thesis:degree_discipline
- Veterinary Pathobiology
- Grantor
- University of Illinois at Urbana-Champaign
- Year dc:date
- 2015
Author and committee
dc:creator, dc:contributor.*- Author dc:creator
-
- Ling, Yan
- Contributors dc:contributor
-
- Silvia N.J.Moreno
Subjects
dc:subject × 1Rights
- Language dc:language
- eng
Identifiers
dc:identifier.*- Identifier
- (MiAaPQ)AAI3199069
- OAI identifier oai:identifier
- oai:www.ideals.illinois.edu:2142/87630